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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 29, No. 6, 2008, pp. 621-626
Bioline Code: zr08095
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 29, No. 6, 2008, pp. 621-626

 en Baclofen Inhibited the Morphine-induced Conditioned Placed Preference and Withdrawal Syndromes
Niu, Hai-chen; Shang, Bin; Sun, Ning-lei; Li, Ling; Guan, Yi-liang; Yu, Hua-lin & Ma, Yuan-ye

Abstract

The mice with a continuous 7-day intraperitoneal injection of morphine was induced the conditioned placed reference (CPP) model and the mice with a continuous 7-day subcutaneous injection of morphine(25, 50, 75, 100, 125, 150 mg/kg)was induced withdrawal model (jump behavior) by naloxone administration(6 mg/kg). The results suggested that the administration of the GABAB receptor agonist, baclofen, could effectively attenuate the expression of CPP and the nalxone-induced response in the mice. It could be concluded that activating GABAB receptor can alleviate physical and psychic dependence syndromes to a certian extent .

Keywords
Morphine; Addiction; Withdrawal; Baclofen; Conditioned placed preference; GABA receptor; Naloxone; Physiological dependence; Psychic-dependence

 
© Copyright 2008 Kunming Institute of Zoology, the Chinese Academy of Sciences
Alternative site location: http://www.zoores.ac.cn/

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