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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 30, No. 2, 2009, pp. 178-184
Bioline Code: zr09028
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 30, No. 2, 2009, pp. 178-184

 en Antibacterial Activity Investigation of Human Semenogelin I Derived Peptides
Gao, Zhen-hua; Zhao, Hui; Yu, Guo-yu; Zhang, Yun; Shen, Ji-hong & Lee, Wen-hui

Abstract

SgI-29 is a newly characterized antibacterial peptide derived from human semenogelin I. Using SgI-29 as model, 4 peptides with different length were synthesized. Physico-chemical characteristics and structure prediction of SgI-29 and its derived peptides were analyzed by software packages and helix-wheel plot. The antibacterial activities of SgI-29 and its derived peptides against Escherichia coli check for this species in other resources ATCC 25922 and Pseudomonas aeruginosa check for this species in other resources ATCC 27853 were determined. The structure-function relationship of SgI-29 and its derivatives was analyzed. Our results indicated that SgI-22 has the strongest antibacterial activities against the tested bacteria among the synthetic peptides and might be used as a good model for the structure optimization.

Keywords
Human Semenogelin I Antibacterial peptide Antibacterial activity

 
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