About Bioline  All Journals  Testimonials  Membership  News

Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 31, No. 1, 2010, pp. 66−76
Bioline Code: zr10010
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 31, No. 1, 2010, pp. 66−76

 en Application Studies of Animal Models in Evaluating Safety and Efficacy of HIV-1 Microbicides
Zhu, Lin; Zhang, Gao-Hong & Zheng, Yong-Tang


As the HIV/AIDS pandemic continues unabated, novel prophylactic strategy for the spread of HIV are urgently needed. Topical microbicides are designed to prevent transmission of HIV when applied vaginally or rectally. Although there are many microbicide candidates in the pipeline, animal models for evaluating their safety and efficacy are urgently needed. On the basis of comparing the non-primate small animal models and the non-human primate animal models in evaluating safety and efficacy of HIV microbicides, this review summarizes the major advantages and disadvantages of the relevant animal models. The suggested direction of research that would benefit the development of microbicides is also reviewed.

HIV-1; Sexual transmission; Microbicide; Safety and efficacy; Animal model

© Copyright 2010 Kunming Institute of Zoology, the Chinese Academy of Sciences
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil