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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 31, No. 1, 2010, pp. 66−76
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Bioline Code: zr10010
Full paper language: Chinese
Document type: Research Article
Document available free of charge
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Zoological Research, Vol. 31, No. 1, 2010, pp. 66−76
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Application Studies of Animal Models in Evaluating Safety and Efficacy of HIV-1 Microbicides
Zhu, Lin; Zhang, Gao-Hong & Zheng, Yong-Tang
Abstract
As the HIV/AIDS pandemic continues unabated, novel prophylactic strategy for the spread of HIV are
urgently needed. Topical microbicides are designed to prevent transmission of HIV when applied vaginally or rectally.
Although there are many microbicide candidates in the pipeline, animal models for evaluating their safety and efficacy
are urgently needed. On the basis of comparing the non-primate small animal models and the non-human primate animal
models in evaluating safety and efficacy of HIV microbicides, this review summarizes the major advantages and
disadvantages of the relevant animal models. The suggested direction of research that would benefit the development of
microbicides is also reviewed.
Keywords
HIV-1; Sexual transmission; Microbicide; Safety and efficacy; Animal model
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© Copyright 2010 Kunming Institute of Zoology, the Chinese Academy of Sciences Alternative site location: http://www.zoores.ac.cn/
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