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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 32, No. 3, 2011, pp. 293-299
Bioline Code: zr11041
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 32, No. 3, 2011, pp. 293-299

 en Correlation between cardiovascular risk factors and the expression of cardiovascular disease related genes in cynomolgus monkeys
Xia, Ji-Liang; Hao, Xiang-Fen; Zeng, Xiao-Ming; Jin, Li-Sha; Zhou, Tong; Li, Xue-Jia; Sun, Yun-Xiao; Rao, Jun-Hua; Liu, Xiao-Ming & Peng, Bai-Lu


The correlation between cardiovascular risk factors and cardiovascular disease related genes plays an important role in early-warning risk and early diagnosis. Thirty middle-aged male crab-eating macaques were fed a moderately atherogenic diet (0.053 mg cholesterol/kJ and 40% of calories as saturated fat) for twelve months. According to cardiovascular risk factors, we selected low-risk and high-risk crab-eating macaques, then analyzed the expression of 113 cardiovascular related genes by real-time PCR. A total of 65 genes were detected in peripheral blood leukocytes by real-time PCR. Sixteen up-regulated genes and nineteen down-regulated genes were detected in low-risk and high-risk crab-eating macaques compared to normal crab-eating macaques (P< 0.05), in addition to fifteen genes that showed unique expression patterns (P< 0.05). We also detected 42 genes in human peripheral blood leukocytes. The expression patterns of 22 genes were consistent between human and crab-eating macaques. These results narrowed the scope of genes for further research.

Cardiovascular diseases; Early-warning risk; Early diagnosis; Crab-eating macaque; Real-time PCR; Peripheral blood leukocytes

© Copyright 2011 Kunming Institute of Zoology, the Chinese Academy of Sciences
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