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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 32, No. 3, 2011, pp. 323-328
Bioline Code: zr11046
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 32, No. 3, 2011, pp. 323-328

 en Acute effects of IL-1β on sodium current in cortical neurons of rats
Qi, Cui; Zhang, Wei-Wei; Wang, Fei; Bao, Chao-Fei; Wang, Xin-Wei; Li, Xiao-Nan; Yu, Xiao-Qing & Zhou, Chen

Abstract

Interleukin-1β (IL-1β ) is an important proinflammatory cytokine that plays a key role in injuries and diseases of the central nervous system (CNS). The voltage-gated Na+channel is the most important ion channel of neurons, and is essential for regenerative action potential (AP). The Na+ channel also contributes to many diseases of the brain. However, relations between IL-1β and central Na+ channels remain unreported. In this study, whole cell patch-clamp recording was used to investigate the acute effects of IL-1β (10 ng/mL) on voltage-dependent Na+ currents and AP of cultured cortical neurons from rats. Results showed that the half-activation voltage of Na+ channels and the threshold of AP, but not the amplitude, slope factor of activation, and inactivation properties, were affected by IL-1β . These data suggest that increased IL-1β in injury and disease may upregulate the excitability of neurons, and thereby exacerbate neurotoxicity.

Keywords
Interleukin-1β;Cortical neurons; Voltage-dependent; Na+ currents;Patch-clamp recording

 
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