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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 32, No. 4, 2011, pp. 421-427
Bioline Code: zr11059
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 32, No. 4, 2011, pp. 421-427

 en A traumatic brain injury model for distinguishing between transplanted neural cells and host cells in vivo
Yang, Shang-Chuan; Dong, Jin-Run; Qu, Jia-Gui; Hu, Xin-Tian & Wang, Zheng-Bo


To perform electrophysiological recording and other investigations on transplanted neural cells in vivo, we used mechanical damage to establish a special traumatic brain injury model that could distinguish transplanted cells from host cells. The morphology of the trauma-induced holes in the cortex of the rat brain was regular. The model was stable and repeatable. Neural stem cells were transplanted into the trauma-induced hole, and were able to survive for a long time. Most of the transplanted cells differentiated into neurons, and only a small amount turned into glia cells. There was a clear boundary between the host cells and the transplanted cells. Single cell electrophysiological recording on transplanted neural cells were detected in vivo. This study established a stable and repeatable traumatic brain injury model, which could be used to conduct in vivo electrophysiological recording research on transplanted neural cells.

Mechanical damaging method; Neural cell; Host cell; Neural stem cells; Traumatic brain injury

© Copyright 2011 Kunming Institute of Zoology, the Chinese Academy of Sciences
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