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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 32, No. 5, 2011, pp. 485-491
Bioline Code: zr11068
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 32, No. 5, 2011, pp. 485-491

 en Over-expression of atf4 in Xenopus check for this species in other resources embryos interferes with neurogenesis and eye formation
LIU, Jian-Tao; YANG, Yong; GUO, Xiao-Gang; CHEN, Miao; DING, Huan-Zhong; CHEN, Yong-Long & WANG, Min-Ru


Accumulated evidence indicates that the activating transcription factor 4 (atf4) is a developmentally relevant gene. Here, we report on the characterization of atf4 in Xenopus check for this species in other resources embryos, which is differentially expressed in the central nervous system, eyes, blood, and the pronephros, as well as in developing endodermal organs such as the stomach, duodenum, liver, and pancreas. Ectopic expression of atf4 in the animal hemisphere of Xenopus embryos had no obvious effects on the induction of neural progenitors, but suppressed neurogenesis and eye formation without promoting apoptosis. Our data suggest that tightly controlled atf4 activities may be crucial for normal neurogenesis and early eye patterning.

Xenopus, atf4, Eye, Neurogenesis, Apoptosis

© Copyright 2011 Kunming Institute of Zoology, the Chinese Academy of Sciences
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