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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 32, No. 6, 2011, pp. 585-595
Bioline Code: zr11085
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 32, No. 6, 2011, pp. 585-595

 en Evolutionary fate and expression patterns of chimeric new genes in Drosophila melanogaster check for this species in other resources
ZHAN, Zu-Bing; ZHANG, Yue; ZHAO, Ruo-Ping & WANG, Wen


Origin and evolution of new genes contribute a lot to genome diversity. New genes usually form chimeric gene structures through DNA-based exon shuffling and generate proteins with novel functions. We investigated polymorphism of 14 chimeric new genes in Drosophila melanogaster check for this species in other resources populations and found that eight have premature stop codons in some individuals while six are intact in the population, four of which are under negative selection, suggesting the two evolutionary fates of new chimeric genes after origination: accumulate premature stop codons and pseudolize, or acquire functions and get fixed by natural selection. Different from new genes originated through RNA-based duplication (retroposition) which are usually testis-specific or male-specific expressed, the expression patterns of these new genes through DNA-based exon shuffling are temporally and spatially diverse, implying that they may have the potential to evolve various biological functions despite that they may become pseudogenes or non-protein-coding RNA genes.

Drosophila melanogaster, Chimeric new genes, Exon shuffling, Expression pattern

© Copyright 2011 Kunming Institute of Zoology, the Chinese Academy of Sciences
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