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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 32, No. 6, 2011, pp. 611-616
Bioline Code: zr11088
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 32, No. 6, 2011, pp. 611-616

 en Rhesus monkey ( Macaca mulatta check for this species in other resources ) muller cells exhibit retinal stem/progenitor cell features in vitro
GUO, Xiang-Yu; JIN, Li-Fang; JI, Shao-Hui & JI, Wei-Zhi


Recent evidences indicate that retinal muller cells exhibit retinal progenitor characteristics under certain condition in chick, rat and human. However, there is no report on nonhuman primate, a close relative to human. In this study, we first established a muller cell line of rhesus monkey expressing GS, vimentin, CRALBP, EGFR, barely GFAP, which resemble the expression profile of human muller cells, differ from that of rodent. Expression of pax6, nestin, sox2, otx2, six6, and six3 was detected after one week culture in neural stem cell medium. Further culture with retinoic acid induced some cells differentiate toward neuron. These results suggest that primate muller cell is capable of dedifferentiating to retinal progenitors, which may serve as a potential cell source for cell therapy to treat retinal degenerative diseases.

Rhesus monkey, Retinal stem cells, Muller cell, Retinal degenerative diseases

© Copyright 2011 Kunming Institute of Zoology, the Chinese Academy of Sciences
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