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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 32, No. 6, 2011, pp. 647-650
Bioline Code: zr11093
Full paper language: Chinese
Document type: Report
Document available free of charge

Zoological Research, Vol. 32, No. 6, 2011, pp. 647-650

 en Role of PTEN in mouse pre-implantation development
WANG, Xi-Hong; HE, Xie-Chao; HAN, Shu-Biao; JI, Wei-Zhi & ZHENG, Ping


The PI3K/Akt signal transduction pathway plays an important role in pre-implantation embryonic development. The tumor suppressor gene PTEN negatively regulates the PI3K/Akt pathway. Although PI3K is constitutively activated during pre-implantation embryonic development, currently no evidence shows the presence and possible involvement of PTEN in early embryo development. We investigated the expression of PTEN protein in germinal vesicle (GV) stage oocytes as well as in pre-implantation embryos. The activated form of PTEN was distributed in the peripheral of GV oocytes and compact morula. Treatment of GV oocytes with PTEN inhibitor bpV(pic) did not affect the maturation of the oocyte, but significantly impaired embryonic development. Thus, our study suggests the necessary role of PTEN in pre-implantation embryonic development.

Oocyte, Pre-implantation embryonic development, PTEN, bpV

© Copyright 2011 Kunming Institute of Zoology, the Chinese Academy of Sciences
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