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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 32, No. 6, 2011, pp. 670-674
Bioline Code: zr11097
Full paper language: Chinese
Document type: Report
Document available free of charge

Zoological Research, Vol. 32, No. 6, 2011, pp. 670-674

 en Effects of propranolol on acquisition and retrieval of morphine- induced conditioned place preference memories in ICR mice
MAO, Yu; YANG, Shang-Chuan; LIU, Chang; MA, Yuan-Ye & HU, Xin-Tian

Abstract

To interfere with the drug-cue memory processes of addicts such as reconsolidation by the administration of the β-adrenergic receptor (β-AR) of norepinephrine (NE) antagonist propranolol (PRO) has become a potential therapy in the future to decrease or inhibit relapse. However, the relationship between PRO and the acquisition or retrieval of morphine-cue memory is not clear.This study examined the effects of PRO on the acquisition and retrieval of memories in morphine-induced conditioned place preference (CPP) mice model. We found that during memory acquisition period, PRO had no effects on the expression and extinction of morphine-CPP, which suggests that the β-AR was irrelevant to the CPP memory acqusition. However, during memoery retrival period, although PRO did not affect the expression of CPP, but it delayed the occurrence of CPP extinction, which indicates that PRO has an inhibit effect on CPP memery extinction, and β-AR plays an important role in modulating the extinction of morphine-CPP. Our study further improved the relationship between drug addiction and β-AR, and proposed a new theory to help developing potential therapy to cure addiction and other neuropsychiatric disorders.

Keywords
β-adrenergic receptor, Memory, Acquisition Retrieval, Opioid, Conditioned place preference

 
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Alternative site location: http://www.zoores.ac.cn/

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