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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 33, No. 1, 2012, pp. 14-18
Bioline Code: zr12003
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 33, No. 1, 2012, pp. 14-18

 en Establishment of tree shrew chronic morphine dependent model
SUN, Yong-Mei; YANG, Jian-Zhen; SUN, Hua-Ying; MA, Yuan-Ye & WANG, Jian-Hong


The clinical use of morphine to reduce pain is limited because of its drug tolerance, dependence and addiction. In the present study, the tree shrews ( Tupaia belangeri chinensis check for this species in other resources ) developed morphine tolerance and chronic morphine dependence by morphine injections with increasing doses (5, 10, 15, 20 mg/kg body weight for 7 days). Meanwhile, the naloxone (1.25 mg/kg body weight)-induced conditioned place aversion (CPA) and the withdrawal symptom were also found. The tree shrew model of chronic morphine dependence can be used to investigate the withdrawal symptoms and to select potential withdrawal symptoms reducing drugs in the future.

Tree shrew; Morphine; Chronic dependence; Conditioned place aversion; Withdrawal symptom

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