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Reproductive traits of polycystic ovary syndrome in female rhesus monkeys
TANG, Xiang-Hui; CAO, Yue-Ling; YANG, Ze-Xing & ZHAO, Fu-Xian
Abstract
The objective of this study was to set up a rhesus monkey model of polycystic ovary syndrome (PCOS),
which is globally prevalent among reproductive-aged human women, and to understand the reproductive traits of PCOS
female monkeys. Six adult female rhesus monkeys aged 6−10 a, were divided into a PCOS group and a control group. The
PCOS group were given two cycles of subcutaneous injections of propionic acid testosterone (PAT), 3.5 mg/kg body
weight, on day 1, day 3, and day 5 of the menstrual cycle, respectively, and then given muscle injections of human
chorionic gonadotropin (HCG), 350 IU/kg body wtight, on day 7, day 9, and day 11, respectively. Results showed that
high levels of serum LH and T [(5.35±0.17) IU/L and (7.58±0.14) ng/mL, respectively], and a high ratio value of LH/FSH
(5.35/1.30=4.12) were observed in the PCOS group. No significant differences were found in serum FSH, E2, and P in the
PCOS group compared with those of the control. Polycystic ovaries in the PCOS monkeys were recorded by live
ultrasound. The blastocysts rates of the PCOS vs. the control were 23.53% vs. 66.67%, and there was a significant
difference between the two groups. This study shows that PAT coupled with HCG can induce PCOS in rhesus monkeys in
the short term. The reproductive features of PCOS monkeys were similar to those of PCOS patients.
Keywords
PCOS; Rhesus monkey; Reproduction; Controlled ovary stimulation
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