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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 33, No. 1, 2012, pp. 55-59
Bioline Code: zr12009
Full paper language: English
Document type: Report
Document available free of charge

Zoological Research, Vol. 33, No. 1, 2012, pp. 55-59

 en Characterization of spontaneous breast tumor in tree shrews ( Tupaia belangeri chinenesis check for this species in other resources )
XIA, Hou-Jun; WANG, Chun-Yan; ZHANG, Hai-Lin; HE, Bao-Li; JIAO, Jian-Lin & CHEN, Ce-Shi

Abstract

Breast cancer is a common malignant tumor. It is essential to develop suitable animal models for discovering novel preventive and therapeutic approaches. Tree shrews ( Tupaia belangeri chinenesis check for this species in other resources ) have a closer evolutionary relationship with humans than do rodents, which have been widely used in laboratory research. Spontaneous breast tumors were identified in tree shrews in 1960s; however, no detailed studies about tree shrew breast tumors have been conducted to date. Here, we characterized a spontaneous breast tumor from tree shrews by Haematoxylin Eosin (H&E) staining. This tumor was identified as a papillary tumor. Immunohistochemical staining (IHC) for progesterone receptor (PR), Ki-67 and cleaved caspase-3 showed that tumor cells were positive for PR, highly proliferative, and less apoptotic compared to normal breast epithelial cells. Thus, the spontaneous tumor of tree shrew is very close to human papillary tumors in terms of morphology and pathology and we concluded that tree shrew may be a suitable animal model for breast cancer research.

Keywords
Spontaneous breast cancer; Tree shrew; Immunohistochemistry

 
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