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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 33, No. 1, 2012, pp. 79-84
Bioline Code: zr12013
Full paper language: English
Document type: Report
Document available free of charge

Zoological Research, Vol. 33, No. 1, 2012, pp. 79-84

 en Comparison of gene expression between naturally occurring and diet-induced T2DM in cynomolgus monkeys
JI, Fang; JIN, Li-Sha; ZENG, Xiao-Ming; ZHANG, Xiu-Juan; ZHANG, Yan-Chun; SUN, Yun-Xiao; GAO, Li-Hua; HE, Hong; RAO, Jun-Hua; LIU, Xiao-Ming & PENG, Bai-Lu

Abstract

To explore pathological alteration of T2DM in cynomolgus monkeys, gene expression profiles of peripheral blood leukocytes from spontaneous and diet-induced T2DM models was analyzed using quantitative real-time PCR. Among 36 T2DM associated genes tested, 19 genes (including G6PC, CCR2B, CTLA4) displayed a similar expression pattern in both spontaneous and diet-induced T2DM models and were significantly up-regulated or down-regulated compared to controls. Interestingly, expression abundance of all up-regulated genes in the diet-induced T2DM was stronger, although not significantly, than spontaneous models, indicating diet-induced T2DM in monkeys should be a reliable research model for changes in gene expression. The characteristic gene expression pattern obtained here may be useful for the clinical diagnosis of T2DM.

Keywords
Type 2 diabetes mellitus (T2DM); Gene expression profile; Cynomolgus monkey

 
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