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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 33, No. 5, 2012, pp. 537-541
Bioline Code: zr12083
Full paper language: English
Document type: Review Article
Document available free of charge

Zoological Research, Vol. 33, No. 5, 2012, pp. 537-541

 en SAMHD1— A HIV-1 restriction factor derived from myeloid lineage monocytes
LI, Pei-Lu; CHEN, Qian-Qian & ZHANG, Chi-Yu

Abstract

HIV-1 restriction factors have became one of the hottest fields of AIDS researches. In 2011, SAMHD1 was demonstrated to be a novel HIV-1 restriction factor, adding to a list of HIV-1 restriction factors that include APOBEC3G, TRIM5α and Tetherin. SAMHD1 is highly expressed in myeloid-lineage monocytes, such as macrophages and dendritic cells. In this paper, we review the current research progress on the structure of SAMHD1, its antiviral mechanism, interaction with the lentivirus Vpx, and evolution. The identification of SAMHD1 opens the door towards understanding the role of SAMHD1 in lentiviral pathogenesis.

Keywords
SAMHD1; HIV-1; Myeloid cells; HIV-1 restriction factor; Vpx

 
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