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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 33, No. 6, 2012, pp. 82-88
Bioline Code: zr12089
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 33, No. 6, 2012, pp. 82-88

 en Involvement of XZFP36L1, an RNA-binding protein, in Xenopus check for this species in other resources neural development
XIA, Yingjie; ZHAO, Shuhua & MAO, Bingyu

Abstract

Xenopus check for this species in other resources ZFP36L1 (zinc finger protein 36, C3H type-like 1) belongs to the ZFP36 family of RNA-binding proteins, which contains two characteristic tandem CCCH-type zinc-finger domains. The ZFP36 proteins can bind AU-rich elements in 3' untranslated regions of target mRNAs and promote their turnover. However, the expression and role of ZFP36 genes during neural development in Xenopus embryos remains largely unknown. The present study showed that Xenopus ZFP36L1 was expressed at the dorsal part of the forebrain, forebrain-midbrain boundary, and midbrain-hindbrain boundary from late neurula stages to tadpole stages of embryonic development. Overexpression of XZFP36L1 in Xenopus embryos inhibited neural induction and differentiation, leading to severe neural tube defects. The function of XZP36L1 requires both its zinc finger and C terminal domains, which also affect its subcellular localization. These results suggest that XZFP36L1 is likely involved in neural development in Xenopus and might play an important role in post-transcriptional regulation.

Keywords
ZFP36L1; RNA-binding protein; Neural development; Xenopus; Post-transcriptional regulation

 
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