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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 34, No. 2, 2013, pp. 59-69
Bioline Code: zr13018
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 34, No. 2, 2013, pp. 59-69

 en Tree shrews under the spot light: emerging model of human diseases
XU, Lin; ZHANG, Yun; LIANG, Bin; LÜ, Long-Bao; CHEN, Ce-Shi; CHEN, Yong-Bin; ZHOU, Ju-Min & YAO, Yong-Gang

Abstract

Animal models are indispensible in biomedical research and have made tremendous contributions to answer fundamental questions on human biology, disease mechanisms, and to the development of new drugs and diagnostic tools. Due to the limitations of rodent models in translational medicine, tree shrews ( Tupaia belangeri chinensis check for this species in other resources ), the closest relative of primates, have attracted increasing attention in modeling human diseases and therapeutic responses. Here we discuss the recent progress in tree shrew biology and the development of tree shrews as human disease models including infectious diseases, metabolic diseases, neurological and psychiatric diseases, and cancers. Meanwhile, the current problems and future perspectives of the tree shrew model are explored.

Keywords
Tree shrew; Experimental animals; Fundamental biology; Animal models of human diseases

 
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