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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 34, No. 2, 2013, pp. 108-115
Bioline Code: zr13026
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 34, No. 2, 2013, pp. 108-115

 en Streptozotocin induction of type 2 diabetes in tree shrew
WU, Xiao-Yun; LI, Yun-Hai; CHANG, Qing; ZHANG, Lin-Qiang; LIAO, Sha-Sha & LIANG, Bin

Abstract

The aim of this study was to induce type 2 diabetes in tree shrew ( Tupaia belangeri chinensis check for this species in other resources ). Streptozotocin (STZ), a glucosamine derivative of nitrosourea and preferentially toxic to pancreatic beta cells, has been commonly used to induce type 1 and 2 diabetes in experimental animals. Tree shrews were treated with different low doses of STZ (60, 70, and 80 mg/kg), with six control tree shrews receiving citrate buffer. After STZ injection, tree shrews displayed increased fasting blood and urine glucose, impaired oral glucose tolerance test, and disturbed lipids metabolism and renal function. However, STZ induced tree shrews showed no diabetic complications such as diabetic lactic acidosis and hyperglycemic hyperosmolar. Animals with the above type 2 diabetic-like symptoms were variable across the three groups from 66.7% to 100%, and mortality ranged from 16.7% to 33.3%. Thus, two 80 mg/kg STZ dose injections were appeared more appropriate than other doses to induce tree shrew model of type 2 diabetes. Our results demonstrated that type 2 diabetes could be induced with favorable STZ application in tree shrew.

Keywords
Tree shrew; Type 2 diabetes; Streptozotocin

 
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