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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 34, No. 5, 2013, pp. 487-492
Bioline Code: zr13076
Full paper language: English
Document type: Report
Document available free of charge

Zoological Research, Vol. 34, No. 5, 2013, pp. 487-492

 en Perinatal clomiphene citrate treatment changes sexual orientations of male mice
HE, Feng-Qin & ZHANG, Heng-Rui

Abstract

Perinatal period and adolescence are critical for brain development, which is the biological basis of an individual's sexual orientation and sexual behavior. In this study, animals were divided into two groups and their sexual orientations were observed: one group experienced drug treatments during the perinatal period, and the other group was castrated at puberty. The results showed that estradiol treatment had no effect on mature male offspring's sexual orientations, but 9 days and 14 days of clomiphene citrate treatment significantly increased the chance of homosexuality and effeminized behavior. In addition, the sexual orientation of mature normal male offspring, which were castrated when they were 21 days old,was not significant different from the control animals. These findings suggest that the inhibition of perinatal estrogen activities could suppress individual male-typical responses, enhance female-typical responses and induce homosexual orientations. Moreover, the masculinizing effects of estrogen were more obvious during perinatal period than adolescence.

Keywords
Perinatal; Clomiphene citrate sodium citrate; Estradiol; Sexual orientation; Castration

 
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