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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 34, No. 6, 2013, pp. 589-595
Bioline Code: zr13093
Full paper language: English
Document type: Report
Document available free of charge

Zoological Research, Vol. 34, No. 6, 2013, pp. 589-595

 en Effect of prefrontal infralimbic cortex GABAA receptor agitating on passive avoidance memory consolidation of rats
WANG, Xiao-Qin & LI, Xian-Li


In this study, one-trial step-through task was applied to reveal the effect of prefrontal infralimbic cortex GABAAreceptor agitating on passive avoidance memory consolidation in rats. Immediately after training (with shock), GABAA receptor agonist, muscimol (0.5 μg/0.25 μL) or saline (0.25 μL) was infused into the test animal's infralimbic cortex, then, the latencies of rats stepping through the dark room were recorded. Meanwhile, local EEG power was adopted as index of the inactivation effect of muscimol. The step-through latencies of muscimol group were comparable(P>0.05)with saline group, but their local EEG power had decreased significantly (P<0.05). These results suggest that the inactivation of infralimbic cortex would not demolish the passive avoidance memory consolidation of rats.

Prefrontal infralimbic cortex; GABAA receptor; Passive avoidance memory consolidation; EEG power; Sprague-Dawley rat; Muscimol

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