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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 35, No. 3, 2014, pp. 196-203
Bioline Code: zr14023
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 35, No. 3, 2014, pp. 196-203

 en Analysis of immunoglobulin, complements and CRP levels in serum of captive northern pig-tailed macaques (Macaca leonina check for this species in other resources )
ZHANG, Xiao-Liang; PANG, Wei; DENG, De-Yao; LV, Long-Bao; FENG, Yue & ZHENG, Yong-Tang


The northern pig-tailed macaque (NPM, Macaca leonina check for this species in other resources ) has become a widely used animal model in biomedical research. In this study, we measured serum immunoglobulin IgG, IgM, IgA, complement C3, C4 and CRP levels in 3-11 year old captive northern pig-tailed macaques using HITACHI 7600-20 automated chemistry analyzer in order to determine the influences of age and gender on these items. The results showed that serum IgA, IgM, C3 and C4 levels were not correlated with age (P>0.05), while serum IgG levels increased progressively with age (r=0.202; P=0.045). Serum IgG, IgA, IgM and C3 levels were higher in females than in males (P<0.05). Moreover, serum C3 concentration was both positively and strongly correlated with that of C4 (r=0.700; P<0.0001). This study provides basic serum immunoglobulin and complement data of captive northern pig-tailed macaques, which may prove useful for future breeding efforts and biomedical research.

Northern pig-tailed macaque (Macaca leonina); Immunoglobulin; Complement; C-reactive protein

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