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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 35, No. 5, 2014, pp. 436-445
Bioline Code: zr14054
Full paper language: English
Document type: Review Article
Document available free of charge

Zoological Research, Vol. 35, No. 5, 2014, pp. 436-445

 en Progress on low susceptibility mechanisms of transmissible spongiform encephalopathies
Qing, Li-Li; Zhao, Hui & Liu, Lin-Lin

Abstract

Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of fatal neurodegenerative diseases detected in a wide range of mammalian species. The “protein-only” hypothesis of TSE suggests that prions are transmissible particles devoid of nucleic acid and the primary pathogenic event is thought to be the conversion of cellular prion protein (PrPC) into the disease-associated isoform (PrPSc). According to susceptibility to TSEs, animals can be classified into susceptible species and low susceptibility species. In this review we focus on several species with low susceptibility to TSEs: dogs, rabbits, horses and buffaloes. We summarize recent studies into the characteristics of low susceptibility regarding protein structure, and biochemical and genetic properties.

Keywords
Transmissible spongiform encephalopathy; Low susceptibility; Dog; Rabbit; Horse; Buffalo; PRNP; SPRN

 
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