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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 35, No. 6, 2014, pp. 485-491
Bioline Code: zr14058
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 35, No. 6, 2014, pp. 485-491

 en Experimental infection of tree shrews( Tupaia belangeri check for this species in other resources ) with Coxsackie virus A16
LI, Jian-Ping; LIAO, Yun; ZHANG, Ying; WANG, Jing-Jing; WANG, Li-Chun; FENG, Kai; LI, Qi-Han & LIU, Long-Ding

Abstract

Coxsackie virus A16 (CA16) is commonly recognized as one of the main human pathogens of hand-foot-mouth disease (HFMD). The clinical manifestations of HFMD include vesicles of hand, foot and mouth in young children and severe inflammatory CNS lesions. In this study, experimentally CA16 infected tree shrews( Tupaia belangeri check for this species in other resources ) were used to investigate CA16 pathogenesis. The results showed that both the body temperature and the percentages of blood neutrophilic granulocytes / monocytes of CA16 infected tree shrews increased at 4-7 days post infection. Dynamic distributions of CA16 in different tissues and stools were found at different infection stages. Moreover, the pathological changes in CNS and other organs were also observed. These findings indicate that tree shrews can be used as a viable animal model to study CA16 infection.

Keywords
Coxsackie virus A16; Infection; Tree shrew

 
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