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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 36, No. 2, 2015, pp. 103-108
Bioline Code: zr15014
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 36, No. 2, 2015, pp. 103-108

 en Sex differences in morphine-induced behavioral sensitization and social behaviors in ICR mice
ZHAN, Bo; MA, Hong-Yuan; WANG, Jian-Li & LIU, Chao-Bao

Abstract

Gender and genetic strain are two prominent variants that influence drug abuse. Although certain sex-related behavioral responses have been previously characterized in ICR mice, little is known about the effects of sex on morphine-induced behavioral responses in this outbred strain. Therefore, in this study, we investigated the sex differences of morphine-induced locomotion, anxiety-like and social behaviors in ICR mice. After morphine or saline exposure for four consecutive days (twice daily), increased locomotion, more time spent in the central area, as well as attenuated rearing and self-grooming behaviors were found in morphine-treated females in an open field; no differences were found in locomotion and the time spent in the central area between male and female controls. When interacting with the same-sex individuals, female controls were engaged in more social investigation, following, body contacting and self-grooming behaviors than controls; morphine exposure reduced contacting and self-grooming behaviors in females; in contrast, these effects were not found in males. These results indicate that female ICR mice are more prosocial and are more susceptible to morphine exposure than males.

Keywords
Morphine; ICR mice; Locomotion; Social behavior

 
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