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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 37, No. 4, 2016, pp. 214-219
Bioline Code: zr16032
Full paper language: English
Document type: Review Article
Document available free of charge

Zoological Research, Vol. 37, No. 4, 2016, pp. 214-219

 en Application of the genome editing tool CRISPR/Cas9 in non-human primates
Luo, Xin; Min, Li & Su, Bing

Abstract

In the past three years, RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats (CRISPR) adaptive immune system has been used to facilitate efficient genome editing in many model and non-model animals. However, its application in nonhuman primates is still at the early stage, though in view of the similarities in anatomy, physiology, behavior and genetics, closely related nonhuman primates serve as optimal models for human biology and disease studies. In this review, we summarize the current proceedings of gene editing using CRISPR/Cas9 in nonhuman primates.

Keywords
CRISPR/Cas9; Non-human primates; Transgene; paCas9; Animal ethics

 
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