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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 37, No. 4, 2016, pp. 246-251
Bioline Code: zr16036
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 37, No. 4, 2016, pp. 246-251

 en Molecular cloning and anti-HIV-1 activities of APOBEC3s from northern pig-tailed macaques ( Macaca leonina check for this species in other resources )
Zhang, Xiao-Liang; Song, Jia-Hao; Pang, Wei & Zheng, Yong-Tang

Abstract

Northern pig-tailed macaques (NPMs, Macaca leonina check for this species in other resources ) are susceptible to HIV-1 infection largely due to the loss of HIV-1-restricting factor TRIM5α. However, great impediments still exist in the persistent replication of HIV-1 in vivo, suggesting some viral restriction factors are reserved in this host. The APOBEC3 proteins have demonstrated a capacity to restrict HIV-1 replication, but their inhibitory effects in NPMs remain elusive. In this study, we cloned the NPM A3A-A3H genes, and determined by BLAST searching that their coding sequences (CDSs) showed 99% identity to the corresponding counterparts from rhesus and southern pig-tailed macaques. We further analyzed the anti-HIV-1 activities of the A3A-A3H genes, and found that A3G and A3F had the greatest anti-HIV-1 activity compared with that of other members. The results of this study indicate that A3G and A3F might play critical roles in limiting HIV-1 replication in NPMs in vivo. Furthermore, this research provides valuable information for the optimization of monkey models of HIV-1 infection.

Keywords
Macaca leonina; Northern pig-tailed macaques; APOBEC3; HIV-1

 
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