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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 38, No. 2, 2017, pp. 96-102
Bioline Code: zr17011
Full paper language: English
Document type: Report
Document available free of charge

Zoological Research, Vol. 38, No. 2, 2017, pp. 96-102

 en Dynamic changes in DNA demethylation in the tree shrew ( Tupaia belangeri chinensis check for this species in other resources ) brain during postnatal development and aging
Wei, Shu; Hua, Hai-Rong; Chen, Qian-Quan; Zhang, Ying; Chen, Fei; Li, Shu-Qing; Li, Fan & Li, Jia-Li

Abstract

Brain development and aging are associated with alterations in multiple epigenetic systems, including DNA methylation and demethylation patterns. Here, we observed that the levels of the 5-hydroxymethylcytosine (5hmC) ten-eleven translocation (TET) enzyme-mediated active DNA demethylation products were dynamically changed and involved in postnatal brain development and aging in tree shrews (Tupaia belangeri chinensis). The levels of 5hmC in multiple anatomic structures showed a gradual increase throughout postnatal development, whereas a significant decrease in 5hmC was found in several brain regions in aged tree shrews, including in the prefrontal cortex and hippocampus, but not the cerebellum. Active changes in Tet mRNA levels indicated that TET2 and TET3 predominantly contributed to the changes in 5hmC levels. Our findings provide new insight into the dynamic changes in 5hmC levels in tree shrew brains during postnatal development and aging processes.

Keywords
Tree shrew; DNA demethylation; 5-hydroxymethylcytosine; Brain development and aging

 
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