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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 38, No. 3, 2017, pp. 146-154
Bioline Code: zr17019
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 38, No. 3, 2017, pp. 146-154

 zh H1N1流感病毒感染IL-1受体敲除小鼠诱发肺部免疫炎症失调与高死亡率
Guo, Lei; Wang, Yan-Cui; Mei, Jun-Jie; Ning, Ruo-Tong; Wang, Jing-Jing; Li, Jia-Qi; Wang, Xi; Zheng, Hui-Wen; Fan, Hai-Tao & Liu, Long-Ding


流感病毒; 肺炎; IL-1受体1; 中性粒细胞

 en Pulmonary immune cells and inflammatory cytokine dysregulation are associated with mortality of IL-1R1-/- mice infected with influenza virus (H1N1)
Guo, Lei; Wang, Yan-Cui; Mei, Jun-Jie; Ning, Ruo-Tong; Wang, Jing-Jing; Li, Jia-Qi; Wang, Xi; Zheng, Hui-Wen; Fan, Hai-Tao & Liu, Long-Ding


Respirovirus infection can cause viral pneumonia and acute lung injury (ALI). The interleukin-1 (IL-1) family consists of proinflammatory cytokines that play essential roles in regulating immune and inflammatory responses in vivo. IL-1 signaling is associated with protection against respiratory influenza virus infection by mediation of the pulmonary anti-viral immune response and inflammation. We analyzed the infiltration lung immune leukocytes and cytokines that contribute to inflammatory lung pathology and mortality of fatal H1N1 virus-infected IL-1 receptor 1 (IL-1R1) deficient mice. Results showed that early innate immune cells and cytokine/chemokine dysregulation were observed with significantly decreased neutrophil infiltration and IL-6, TNF-α, G-CSF, KC, and MIP-2 cytokine levels in the bronchoalveolar lavage fluid of infected IL-1R1-/- mice in comparison with that of wild type infected mice. The adaptive immune response against the H1N1 virus in IL-1R1-/- mice was impaired with downregulated anti-viral Th1 cell, CD8+ cell, and antibody functions, which contributes to attenuated viral clearance. Histological analysis revealed reduced lung inflammation during early infection but severe lung pathology in late infection in IL-1R1-/- mice compared with that in WT infected mice. Moreover, the infected IL-1R1-/- mice showed markedly reduced neutrophil generation in bone marrow and neutrophil recruitment to the inflamed lung. Together, these results suggest that IL-1 signaling is associated with pulmonary anti-influenza immune response and inflammatory lung injury, particularly via the influence on neutrophil mobilization and inflammatory cytokine/chemokine production.

Influenza; Lung inflammation; IL-1 receptor 1; Neutrophil

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