Kunming Institute of Zoology, Chinese Academy of Sciences
Vol. 38, No. 4, 2017, pp. 171-179
Bioline Code: zr17022
Full paper language: English
Document type: Review Article
Document available free of charge
Zoological Research, Vol. 38, No. 4, 2017, pp. 171-179
© Copyright 2017 - Zoological Research
Models and detection of spontaneous recurrent seizures in laboratory rodents|
Gu, Bin & Dalton, Katherine A.
Epilepsy, characterized by spontaneous recurrent seizures (SRS), is a serious and common neurological disorder afflicting an estimated 1% of the population worldwide. Animal experiments, especially those utilizing small laboratory rodents, remain essential to understanding the fundamental mechanisms underlying epilepsy and to prevent, diagnose, and treat this disease. While much attention has been focused on epileptogenesis in animal models of epilepsy, there is little discussion on SRS, the hallmark of epilepsy. This is in part due to the technical difficulties of rigorous SRS detection. In this review, we comprehensively summarize both genetic and acquired models of SRS and discuss the methodology used to monitor and detect SRS in mice and rats.
Spontaneous recurrent seizures; Animal model; Epilepsy
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