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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 38, No. 4, 2017, pp. 171-179
Bioline Code: zr17022
Full paper language: English
Document type: Review Article
Document available free of charge

Zoological Research, Vol. 38, No. 4, 2017, pp. 171-179

 zh 自发性癫痫在啮齿类实验动物中的模型和探测
Gu, Bin & Dalton, Katherine A.


以自发性癫痫为特征的癫痫症是一种常见的神经系统疾病。全世界大概有百分之一的人口患有该症。动物实验,特别是利用小型啮齿类实验动物,仍是研究癫痫症潜在机制,并进一步预防,诊断和治疗癫痫症的基础。虽然现在有很多癫痫症动物模型研究已经把注意力放到了癫痫的发病机理上,但是由于检测困难,关于自发性癫痫的探讨却很少。本篇综述总结了大小鼠遗传型和获得型自发性癫痫模型,并进一步探讨了自发性癫痫的记录和探测方法。


自发性癫痫;动物模型;癫痫症

 
 en Models and detection of spontaneous recurrent seizures in laboratory rodents
Gu, Bin & Dalton, Katherine A.

Abstract

Epilepsy, characterized by spontaneous recurrent seizures (SRS), is a serious and common neurological disorder afflicting an estimated 1% of the population worldwide. Animal experiments, especially those utilizing small laboratory rodents, remain essential to understanding the fundamental mechanisms underlying epilepsy and to prevent, diagnose, and treat this disease. While much attention has been focused on epileptogenesis in animal models of epilepsy, there is little discussion on SRS, the hallmark of epilepsy. This is in part due to the technical difficulties of rigorous SRS detection. In this review, we comprehensively summarize both genetic and acquired models of SRS and discuss the methodology used to monitor and detect SRS in mice and rats.

Keywords
Spontaneous recurrent seizures; Animal model; Epilepsy

 
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