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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 38, No. 4, 2017, pp. 198-202
Bioline Code: zr17025
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 38, No. 4, 2017, pp. 198-202

 zh Humanin基因的假基因化普遍存在于若干脊椎动物的线粒体DNA中
Logan, Ian S.


人类的Humanin肽由Humanin基因编码,Humanin基因位于线粒体编码16S核糖体RNA的基因中。Humanin肽能有效预防若干组织的细胞死亡,并提高我们对动物模型的认知。通过使用简单的数据挖掘技术,结果显示:在GenBank数据库中,99.4%的人类Humanin基因序列不受突变的影响。然而,在其他脊椎动物中,Humanin基因的假基因化是一个普遍特征:在某些物种中显然随机出现,而在其他物种并非如此。功能性Humanin基因的存留或丢失可能是实验室动物的一个重要参数,尤其是如果将其用作阿尔茨海默病(AD)研究中的动物模型。Humanin基因在进化过程中,在一些脊椎动物物种中经历假基因化的确切原因尚待确定。本研究最初是为了查看有关Humanin基因的可用信息,然而令人惊异的发现是,假基因化发生在mtDNA的一个基因中,而不仅仅是限于染色体基因。


mtDNA;Humanin;假基因化;NUMT

 
 en Pseudogenization of the Humanin gene is common in the mitochondrial DNA of many vertebrates
Logan, Ian S.

Abstract

In the human the peptide Humanin is produced from the small Humanin gene which is embedded as a gene-within-a-gene in the 16S ribosomal molecule of the mitochondrial DNA (mtDNA). The peptide itself appears to be significant in the prevention of cell death in many tissues and improve cognition in animal models. By using simple data mining techniques, it is possible to show that 99.4% of the human Humanin sequences in the GenBank database are unaffected by mutations. However, in other vertebrates, pseudogenization of the Humanin gene is a common feature; occurring apparently randomly in some species and not others. The persistence, or loss, of a functional Humanin gene may be an important factor in laboratory animals, especially if they are being used as animal models in studies of Alzheimer\'s disease (AD). The exact reason why Humanin underwent pseudogenization in some vertebrate species during their evolution remains to be determined. This study was originally planned to review the available information about Humanin and it was a surprise to be able to show that pseudogenization has occurred in a gene in the mtDNA and is not restricted solely to chromosomal genes.

Keywords
mtDNA; Humanin; Pseudogenization; NUMT

 
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Alternative site location: http://www.zoores.ac.cn/

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