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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 39, No. 1, 2018, pp. 3-14
Bioline Code: zr18002
Full paper language: English
Document type: Review Article
Document available free of charge

Zoological Research, Vol. 39, No. 1, 2018, pp. 3-14

 en Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential
Wong, Gary & Qiu, Xiang-Guo

Abstract

Due to their inability to generate a complete immune response, mice knockout for type I interferon (IFN) receptors (Ifnar–/–) are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the Flaviviridae check for this species in other resources , Filoviridae, Arenaviridae, Bunyaviridae, Henipaviridae check for this species in other resources , and Togaviridae. In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.

Keywords
Ifnar; Mice; Animal model; Flavivirus; Filovirus; Arenavirus; Bunyavirus; Henipavirus; Togavirus

 
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