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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 39, No. 1, 2018, pp. 15-24
Bioline Code: zr18003
Full paper language: English
Document type: Review Article
Document available free of charge

Zoological Research, Vol. 39, No. 1, 2018, pp. 15-24

 en Animal models for filovirus infections
Siragam, Vinayakumar; Wong, Gary & Qiu, Xiang-Guo

Abstract

The family Filoviridae, which includes the genera Marburgvirus check for this species in other resources and Ebolavirus check for this species in other resources , contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.

Keywords
Filovirus; Ebola virus; Marburg virus; Marburg virus disease; Ebola virus disease; Mouse-adapted ebolavirus; Guinea-pig-adapted ebolavirus; Sudan virus; Plaque-forming units

 
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