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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 39, No. 1, 2018, pp. 25-31
Bioline Code: zr18004
Full paper language: English
Document type: Review Article
Document available free of charge

Zoological Research, Vol. 39, No. 1, 2018, pp. 25-31

 en Animal models for the study of hepatitis B virus infection
Guo, Wei-Na; Zhu, Bin; Ai, Ling; Yang, Dong-Liang & Wang, Bao-Ju

Abstract

Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV) worldwide. Current antiviral therapies, including interferon and nucleot(s)ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection.

Keywords
Hepatitis B virus; Animal model; Duck hepatitis B virus; Woodchuck hepatitis virus

 
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