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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 39, No. 2, 2018, pp. 72-86
Bioline Code: zr18009
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 39, No. 2, 2018, pp. 72-86

 en Kidney disease models: tools to identify mechanisms and potential therapeutic targets
Bao, Yin-Wu; Yuan, Yuan; Chen, Jiang-Hua & Lin, Wei-Qiang

Abstract

Acute kidney injury (AKI) and chronic kidney disease (CKD) are worldwide public health problems affecting millions of people and have rapidly increased in prevalence in recent years. Due to the multiple causes of renal failure, many animal models have been developed to advance our understanding of human nephropathy. Among these experimental models, rodents have been extensively used to enable mechanistic understanding of kidney disease induction and progression, as well as to identify potential targets for therapy. In this review, we discuss AKI models induced by surgical operation and drugs or toxins, as well as a variety of CKD models (mainly genetically modified mouse models). Results from recent and ongoing clinical trials and conceptual advances derived from animal models are also explored.

Keywords
Acute kidney injury; Chronic kidney disease; Mouse models; Transgenic mice

 
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