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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 40, No. 6, 2019, pp. 488-505
Bioline Code: zr19049
Full paper language: English
Document type: Review Article
Document available free of charge

Zoological Research, Vol. 40, No. 6, 2019, pp. 488-505

 en Antimicrobial peptides: new hope in the war against multidrug resistance
Mwangi, James; Hao, Xue; Lai, Ren & Zhang, Zhi-Ye

Abstract

The discovery of antibiotics marked a golden age in the revolution of human medicine. However, decades later, bacterial infections remain a global healthcare threat, and a return to the pre-antibiotic era seems inevitable if stringent measures are not adopted to curb the rapid emergence and spread of multidrug resistance and the indiscriminate use of antibiotics. In hospital settings, multidrug resistant (MDR) pathogens, including carbapenem-resistant Pseudomonas aeruginosa check for this species in other resources , vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus check for this species in other resources (MRSA), and extended-spectrum β-lactamases (ESBL) bearing Acinetobacter baumannii check for this species in other resources , Escherichia coli check for this species in other resources , and Klebsiella pneumoniae check for this species in other resources are amongst the most problematic due to the paucity of treatment options, increased hospital stay, and exorbitant medical costs. Antimicrobial peptides (AMPs) provide an excellent potential strategy for combating these threats. Compared to empirical antibiotics, they show low tendency to select for resistance, rapid killing action, broad-spectrum activity, and extraordinary clinical efficacy against several MDR strains. Therefore, this review highlights multidrug resistance among nosocomial bacterial pathogens and its implications and reiterates the importance of AMPs as next-generation antibiotics for combating MDR superbugs.

Keywords
Multidrug resistance; Nosocomial infections; Antimicrobial peptide; Antibiotic alternatives

 
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