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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 40, No. 6, 2019, pp. 522-531
Bioline Code: zr19051
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 40, No. 6, 2019, pp. 522-531

 en Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques ( Macaca leonina check for this species in other resources )
Zhang, Ming-Xu; Song, Tian-Zhang; Zheng, Hong-Yi; Wang, Xue-Hui; Lu, Ying; Zhang, Han-Dan; Li, Ting; Pang, Wei & Zheng, Yong-Tang

Abstract

Microbial translocation is a cause of systemic immune activation in HIV/SIV infection. In the present study, we found a lower CD8+ T cell activation level in Macaca leonina (northern pig-tailed macaques, NPMs) than in Macaca mulatta check for this species in other resources (Chinese rhesus macaques, ChRMs) during SIVmac239 infection. Furthermore, the levels of plasma LPS-binding protein and soluble CD14 in NPMs were lower than those in ChRMs. Compared with ChRMs, SIV-infected NPMs had lower Chiu scores, representing relatively normal intestinal mucosa. In addition, no obvious damage to the ileum or colon epithelial barrier was observed in either infected or uninfected NPMs, which differed to that found in ChRMs. Furthermore, no significant microbial translocation ( Escherichia coli check for this species in other resources ) was detected in the colon or ileum of infected or uninfected NPMs, which again differed to that observed in ChRMs. In conclusion, NPMs retained superior intestinal integrity and limited microbial translocation during SIV infection, which may contribute to their lower immune activation compared with ChRMs.

Keywords
Immune activation; Intestinal integrity; Microbial translocation; SIVmac239; Macaca leonina; Northern pig-tailed macaques; Macaca mulatta; Chinese rhesus macaques

 
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