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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 41, No. 5, 2020, pp. 503-516
Bioline Code: zr20053
Full paper language: English
Document type: Editorial
Document available free of charge

Zoological Research, Vol. 41, No. 5, 2020, pp. 503-516

 en Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques
Song, Tian-Zhang; Zheng, Hong-Yi; Han, Jian-Bao; Jin, Lin; Yang, Xiang; Liu, Feng-Liang; Luo, Rong-Hua; Tian, Ren-Rong; Cai, Hou-Rong; Feng, Xiao-Li; Liu, Chao; Li, Ming-Hua & Zheng, Yong-Tang

Abstract

As of June 2020, Coronavirus Disease 2019 (COVID-19) has killed an estimated 440 000 people worldwide, 74% of whom were aged ≥65 years, making age the most significant risk factor for death caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To examine the effect of age on death, we established a SARS-CoV-2 infection model in Chinese rhesus macaques ( Macaca mulatta check for this species in other resources ) of varied ages. Results indicated that infected young macaques manifested impaired respiratory function, active viral replication, severe lung damage, and infiltration of CD11b+ and CD8+ cells in lungs at one-week post infection (wpi), but also recovered rapidly at 2 wpi. In contrast, aged macaques demonstrated delayed immune responses with a more severe cytokine storm, increased infiltration of CD11b+ cells, and persistent infiltration of CD8+ cells in the lungs at 2 wpi. In addition, peripheral blood T cells from aged macaques showed greater inflammation and chemotaxis, but weaker antiviral functions than that in cells from young macaques. Thus, the delayed but more severe cytokine storm and higher immune cell infiltration may explain the poorer prognosis of older aged patients suffering SARS-CoV-2 infection.

Keywords
COVID-19; Non-human primate animal model; Elderly; Immune response

 
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