search
for
 About Bioline  All Journals  Testimonials  Membership  News


Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 41, No. 6, 2020, pp. 632-643
Bioline Code: zr20070
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 41, No. 6, 2020, pp. 632-643

 en Transcriptomic analyses of humans and mice provide insights into depression
Li, Hui-Juan; Su, Xi; Zhang, Lu-Wen; Zhang, Chu-Yi; Wang, Lu; Li, Wen-Qiang; Yang, Yong-Feng; Lv, Lu-Xian; Li, Ming & Xiao, Xiao

Abstract

Accumulating studies have been conducted to identify risk genes and relevant biological mechanisms underlying major depressive disorder (MDD). In particular, transcriptomic analyses in brain regions engaged in cognitive and emotional processes, e.g., the dorsolateral prefrontal cortex (DLPFC), have provided essential insights. Based on three independent DLPFC RNA-seq datasets of 79 MDD patients and 75 healthy controls, we performed differential expression analyses using two alternative approaches for cross-validation. We also conducted transcriptomic analyses in mice undergoing chronic variable stress (CVS) and chronic social defeat stress (CSDS). We identified 12 differentially expressed genes (DEGs) through both analytical methods in MDD patients, the majority of which were also dysregulated in stressed mice. Notably, the mRNA level of the immediate early gene FOS (Fos proto-oncogene) was significantly decreased in both MDD patients and CVS-exposed mice, and CSDS-susceptible mice exhibited a greater reduction in Fos expression compared to resilient mice. These findings suggest the potential key roles of this gene in the pathogenesis of MDD related to stress exposure. Altered transcriptomes in the DLPFC of MDD patients might be, at least partially, the result of stress exposure, supporting that stress is a primary risk factor for MDD.

Keywords
 Major  depressive  disorder; Stressed mice; Dorsolateral prefrontal cortex; Transcriptomic analysis; FOS

 
© Copyright 2020 - Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences
Alternative site location: http://www.zoores.ac.cn/

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil