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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 42, No. 1, 2021, pp. 14-27
Bioline Code: zr21003
Full paper language: English
Document type: Review Article
Document available free of charge

Zoological Research, Vol. 42, No. 1, 2021, pp. 14-27

 en Dmrt1 regulates the immune response by repressing the TLR4 signaling pathway in goat male germline stem cells
Wei, Yu-Dong; Du, Xiao-Min; Yang, Dong-Hui; Ma, Fang-Lin; Yu, Xiu-Wei; Zhang, Meng-Fei; Li, Na; Peng, Sha; Liao, Ming-Zhi; Li, Guang-Peng; Bai, Chun-Ling; Liu, Wei-Shuai & Hua, Jin-Lian


Double sex and mab-3-related transcription factor 1 (Dmrt1), which is expressed in goat male germline stem cells (mGSCs) and Sertoli cells, is one of the most conserved transcription factors involved in sex determination. In this study, we highlighted the role of Dmrt1 in balancing the innate immune response in goat mGSCs. Dmrt1 recruited promyelocytic leukemia zinc finger (Plzf), also known as zinc finger and BTB domain-containing protein 16 (Zbtb16), to repress the Toll-like receptor 4 (TLR4)-dependent inflammatory signaling pathway and nuclear factor (NF)-κB. Knockdown of Dmrt1 in seminiferous tubules resulted in widespread degeneration of germ and somatic cells, while the expression of proinflammatory factors were significantly enhanced. We also demonstrated that Dmrt1 stimulated proliferation of mGSCs, but repressed apoptosis caused by the immune response. Thus, Dmrt1 is sufficient to reduce inflammation in the testes, thereby establishing the stability of spermatogenesis and the testicular microenvironment.

Male germline stem cells (mGSCs); Goat; Dmrt1; Plzf; Immune response

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