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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 42, No. 2, 2021, pp. 141-152
Bioline Code: zr21017
Full paper language: English
Document type: Review Article
Document available free of charge

Zoological Research, Vol. 42, No. 2, 2021, pp. 141-152

 en Animal secretory endolysosome channel discovery
Zhang, Yun; Wang, Qi-Quan; Zhao, Zhong & Deng, Cheng-Jie

Abstract

Secretory pore-forming proteins (PFPs) have been identified in organisms from all kingdoms of life. Our studies with the toad species Bombina maxima check for this species in other resources found an interaction network among aerolysin family PFPs (af-PFPs) and trefoil factors (TFFs). As a toad af-PFP, BmALP1 can be reversibly regulated between active and inactive forms, with its paralog BmALP3 acting as a negative regulator. BmALP1 interacts with BmTFF3 to form a cellular active complex called βγ-CAT. This PFP complex is characterized by acting on endocytic pathways and forming pores on endolysosomes, including stimulating cell macropinocytosis. In addition, cell exocytosis can be induced and/or modulated in the presence of βγ-CAT. Depending on cell contexts and surroundings, these effects can facilitate the toad in material uptake and vesicular transport, while maintaining mucosal barrier function as well as immune defense. Based on experimental evidence, we hereby propose a secretory endolysosome channel (SELC) pathway conducted by a secreted PFP in cell endocytic and exocytic systems, with βγ-CAT being the first example of a SELC protein. With essential roles in cell interactions and environmental adaptations, the proposed SELC protein pathway should be conserved in other living organisms.

Keywords
Pore-forming protein; Secretory endolysosome channel (SELC); Endocytosis; Exocytosis; Vesicular transport

 
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