In this study, an analysis of the copper (Cu) and lead (Pb) content in the tissue of the green mussel, Perna viridis
, and its relationship with the activity of the enzymes glycogen synthetase and glycogen phosphorylase, in order to determine the influence of these chemical pollutants on those. The analysis of the glycogen and the enzymatic activity were carried out, according to the methodology AOAC (1991), Thomas (1968) and Rúa et al
. (1988) respectively, using spectrometry of visible light. Heavy metal concentration was determined APHA (1985), using atomic absorption spectrometry. The results point out that the metals Cu and Pb inhibited the activity of both enzymes, necessary for the synthesis and mobilization of the glycogen, what could have a negative effect so much in the process of reproduction of this species, as well in the fisheries and commercialization of the product.