About Bioline  All Journals  Testimonials  Membership  News

Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 5, No. 1, 2006, pp. 35-41
Bioline Code: pt06005
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pharmacology and Therapeutics, Vol. 5, No. 1, 2006, pp. 35-41

 en Antimicrobial and Antioxidant Activities of Careya arborea   check for this species in other resources Roxb. Stem Bark
Kumar, Ramanathan Sambath; Sivakumar, Thangavel; sundaram, Rajagopal Shanmuga; Sivakumar, Palanavel; Nethaji, Ramalingam; Gupta, Malaya & Mazumdar, Upal Kanti


The present study was carried out to evaluate the antimicrobial and antioxidant activities of methanol extract of Careya arborea (MECA) stem barks (Myrtaceae) in various in-vitro systems. Antimicrobial activities of MECA were carried out using disc diffusion methods with Gram positive and Gram negative bacteria and some fungal species. MECA showed broad-spectrum antimicrobial activity against all tested microorganisms. Antioxidant and free radical scavenging activities of MECA was assessed by using 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH), superoxide anion radical, nitric oxide radical and hydroxyl radical scavenging assays. The antioxidant activity of MECA increased in a concentration dependent manner. In DPPH radical scavenging assay the IC50 value of the extract was found to be 132.25 mg/mL. MECA was found to inhibit the nitric oxide radicals generated from sodium nitroprusside. The IC50 value was found to be 72.54 mg/mL, whereas the IC50 value of curcumin was 20.4 mg/mL. Moreover, the MECAwas found to scavenge the superoxide generated by phenazine methosulphate (PMS) / nicotinamide adenine dinucleotide (NADH)-nitroblue tetrazolium (NBT) system. MECA was also found to inhibit the hydroxyl radical generated by Fenton’s reaction, where the IC50 value of MECA was found to be more than 1000 mg/mL and for catechin the IC50 value was found to be 5 mg/mL. The results obtained in the present study indicate that the MECA can be a potential source of natural antimicrobial and antioxidant agents.

Careya arborea, Antimicrobial activity, Antioxidant activity, Free radical scavenging, DPPH assay

© Copyright 2006 - Razi Institute for Drug Research (RIDR)
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil