search
for
 About Bioline  All Journals  Testimonials  Membership  News


Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 5, No. 2, 2006, pp. 127-130
Bioline Code: pt06021
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pharmacology and Therapeutics, Vol. 5, No. 2, 2006, pp. 127-130

 en Pharmacokinetics and Dosage Regimen of Cefepimefollowing Single Dose Intravenous Administration in Calves
Patel, Urvesh D; Bhavsar, Shailesh K & Thaker, Aswin M

Abstract

Pharmacokinetics of cefepimewas studied after single dose intravenous administration at the dose rate of 5 mg/kg body weight in calves. Blood samples were collected from the jugular vein at predetermined time intervals before and after drug administration. Serum was harvested and analysed for cefepimeconcentration by reverse-phase high performance liquid chromatography. Following intravenous administration, the mean serum cefepimelevel of 44.93 ± 5.47 μg/mL was observed at 0.033 h (2 minutes). The therapeutically effective concentration of cefepime(≥ 1.00 μg/mL) was maintained in serum up to 12 h. The distribution half-life (t1/2a) and elimination half-life (t1/2β) were 0.09 ± 0.01 hand 3.70 ± 0.16 h, respectively. The mean values of apparent volume of distribution [Vd(area)] and volume of distribution of drug at steady-state (Vd (ss)) were calculated to be 0.57 ± 0.03 and 0.43 ± 0.03 L/kg, respectively. The mean value of total body clearance (ClB) was 1.81 ± 0.16 mL/min/kg. The average values for area under serum drug concentration-time curve (AUC) and area under first moment of curve (AUMC) were 47.73 ± 4.05 μgh/mL and 190.3 ± 19.9 μg h2/mL. The average value of mean residence time (MRT) was 3.95 ± 0.11 h. A satisfactory intravenous dosage regimen would be 4.20 mg/kg body weight as priming dose followed by 3.78 mg/kg repeated at 12 h intervals.

Keywords
Cefepime, Calves, Pharmacokinetics, Intravenous

 
© Copyright 2006 - Razi Institute for Drug Research (RIDR)
Alternative site location: http://ijpt.iums.ac.ir/

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil