Instructions to Authors
Manuscripts must be prepared in accordance with "Uniform requirements for
Manuscripts submitted to Biomedical Journal" developed by International
Committee of Medical Journal Editors (October 2004). The uniform requirements
and specific requirement of Journal of Cancer Research and Therapeutics are
summarized below. Before sending a manuscript contributors are requested to
check for the
latest instructions available. Instructions are also available from the website
of the journal (http://www.cancerjournal.net) and from the manuscript submission
site (http://www.journalonweb.com/jcrt ).
The Editorial Process
The manuscripts will be reviewed for possible publication with the understanding
that they are being submitted to one journal at a time and have not been published,
simultaneously submitted, or already accepted for publication elsewhere.
The Editors review all submitted manuscripts initially. Manuscripts with insufficient
originality, serious scientific flaws, or absence of importance of message
are rejected. On an average 20% of manuscripts get rejected at the initial
stages. All manuscripts received are duly acknowledged. The journal will not
return the unaccepted manuscripts. Other manuscripts are sent to two or more
expert reviewers without revealing the identity of the contributors to the
reviewers. Each manuscript is also assigned to a member of the editorial team,
who based on the comments from the reviewers takes a final decision on the
manuscript. Within a period of 10 to 12 weeks, the contributors will be informed
about the reviewers' comments and acceptance/rejection of manuscript. On an
average, the submission to first decision period was less than 32 days in the
year 2004. Up to 70% of the manuscripts submitted to the journal do not get
Articles accepted would be copy edited for grammar, punctuation, print style,
and format. Page proofs will be sent to the first contributor, which has
to be returned within three days. Correction received after that period may
The contributor may provide names of two or three qualified reviewers who
have had experience in the subject of the submitted manuscript, but who are
not affiliated with the same institutes as the contributor/s.
Types of Manuscripts and Limits
- Original articles: Randomized controlled trials, intervention studied, studies
of screening and diagnostic test, outcome studies, cost effectiveness analyses,
case-control series, and surveys with high response rate. Up to 3000 words
excluding references and abstract.
- Review articles: Systemic critical assessments of literature
and data sources. Up to 4000 words excluding references and abstract.
- Case reports: new/interesting/very rare cases can be reported.
Cases with clinical significance or implications will be given priority,
whereas, mere reporting
of a rare case may not be considered. Up to 1000 words excluding references
and abstract and up to 10 references.
- Letter to the Editor: Should be short, decisive observation.
They should not be preliminary observations that need a later paper
for validation. Up to 400
words and 4 references.
- Announcements of conferences, meetings, courses, awards, and other
items likely to be of interest to the readers should be submitted
name and address
of the person from whom additional information can be obtained. Up
to 100 words.
Authorship credit should be based only on substantial contributions
- to conception and design or acquisition of data or analysis and interpretation
- drafting the article or revising it critically for important intellectual
- final approval of the version to be published.
Conditions 1, 2, and 3 must
all be met. Participation solely in the acquisition of funding or the
collection of data does not justify authorship. General
supervision of the research group is not sufficient for authorship. Each
have participated sufficiently in the work to take public responsibility
for appropriate portions of the content.
The order of naming the contributors should be based on the relative contribution
of the contributor towards the study and writing the manuscript. Once submitted
the order cannot be changed without written consent of all the contributors.
For a study from in a single institute the number of contributors should not
exceed six. For a case-report, images, Letter to the Editor and review article
the number of contributors should not exceed four. A justification should be
included, if the number of contributors exceeds these limits.
Only those who have done substantial work in a particular field can write
a review article. A short summary of the work done by the contributor(s) in
the field of review should accompany the manuscript. The journal expects the
contributors to give post-publication updates on the subject of review. The
update should be brief, covering the advances in the field after the publication
of article and should be sent as letter to editor, as and when major development
occur in the field.
Contributors should provide a description of what each of them contributed
towards the manuscript. Description should be divided in following categories,
as applicable: concepts, design, definition of intellectual content, literature
search, clinical studies, experimental studies, data acquisition, data analysis,
statistical analysis, manuscript preparation, manuscript editing, and manuscript
review. Authors' contributions will be printed on the first page of the article.
One or more author should take responsibility of the integrity of the work
as a whole from inception to published article and should be designated as
Sending the Manuscript to the Journal
Send three copies of the manuscript along with a covering letter, contributors'
form signed by all the contributors, checklist and floppy in a heavy-paper
envelope. Place the photographs in a separate heavy-paper envelope. The covering
letter must include
- A full statement to the editor about all submissions and previous reports
that might be regarded as redundant publication of the same or very similar
work. Any such work should be referred to specifically, and referenced
in the new paper. Copies of such material should be included with the submitted
to help the editor decide how to handle the matter.
- A statement of financial or other relationships that might lead to a conflict
of interest, if that information is not included in the manuscript
itself or in an authors' form
- A statement that the manuscript has been read and approved by all the
authors, that the requirements for authorship as stated earlier in this document
been met, and that each author believes that the manuscript represents
honest work, if that information is not provided in another form (see below);
- The name, address, and telephone number of the corresponding author,
who is responsible for communicating with the other authors about revisions
approval of the proofs, if that information is not included on the
Copies of any permission(s) to reproduce published material, and to
use illustrations or report information about identifiable people
Copies of any and all published articles or other manuscripts in
preparation or submitted elsewhere that are related to the manuscript must
accompany the manuscript. The manuscript should be sent to Journal
of Cancer Research
and Therapeutics, Department of Radiation Oncology, Nanavati Hospital,
Vile Parle, Mumbai, India.
Online Submission of the Manuscripts
Articles can also be submitted online from http://www.journalonweb.com. New
authors will have to register as author, which is a simple two step procedure.
For online submission articles should be prepared in two files (first page
file and article file). Images should be submitted separately.
- First Page File: Prepare the title page, covering letter, acknowledgement,
etc. using a word processor program. All information which can reveal your
identity should be here. Use text/rtf/doc/PDF files. Do not zip the files.
- Article file: The main text of the article, beginning from Abstract till
References (including tables) should be in this file. Do not include any
as acknowledgement, your names in page headers, etc.) in this file. Use
text/rtf/doc/PDF files. Do not zip the files. Limit the file size to 400
kb. Do not incorporate
images in the file. If file size is large, graphs can be submitted as images
separately without incorporating them in the article file to reduce the
size of the file.
- Images: Submit good quality color images. Each image should be less than
100 kb in size. Size of the image can be reduced by decreasing the actual
and width of the images (keep up to 400 pixels or 3 inches). All image
formats (jpeg, tiff, gif, bmp, png, eps, etc.) are acceptable; jpeg is
Do not zip the files.
- Legends: Legends for the figures/images should be included at the end
of the article file.
If the manuscript is submitted online, the contributors' form and copyright
transfer form has to be submitted in original with the signatures of all the
contributors within two weeks from submission. Hard copies of the images (one
set), for articles submitted online, should be sent to the journal office at
the time of submission of a revised manuscript.
Preparation of the Manuscript
The text of observational and experimental articles should be divided into
sections with the headings: Introduction, Methods, Results, Discussion, References,
Tables, Figures, Figure legends, and Acknowledgment. Do not make subheadings
in these sections. Send laser printout, on white thick paper, of A4 size
(212 × 297 mm), with margins of 25 mm (1 inch) from all the four sides.
Type or print on only one side of the paper. Use double spacing throughout.
Number pages consecutively, beginning with the title page. The language should
be British English.
The title page should carry
- Type of manuscript (e.g. Original article, Case Report)
- The title of the article, which should be concise, but informative;
- Running title or short title not more than 50 characters;
- The name by which each contributor is known (Last name, First name and
initials of middle name), with his or her highest academic degree(s) and
- The name of the department(s) and institution(s) to which the work should
- The name, address, phone numbers, facsimile numbers and e-mail address
of the contributor responsible for correspondence about the manuscript;
- The total number of pages, total number of photographs and word counts
separately for abstract and for the text (excluding the references and abstract);
- Source(s) of support in the form of grants, equipment, drugs, or all of
- Acknowledgement, if any; and
If the manuscript was presented as part at a
meeting, the organization, place, and exact date on which it was read.
The second page should carry the full title of the manuscript and an abstract
(of no more than 150 words for case reports, brief reports and 250 words
for original articles). The abstract should be structured and state the Context
(Background), Aims, Settings and Design, Methods and Material, Statistical
analysis used, Results and Conclusions. Below the abstract should provide
3 to 10 key word.
State the purpose of the article and summaries the rationale for the study
The Methods section should include only information that was available at
the time the plan or protocol for the study was written; all information obtained
during the conduct of the study belongs in the Results section.
Selection and Description of Participants: Describe your selection of the
observational or experimental participants (patients or laboratory animals,
including controls) clearly, including eligibility and exclusion criteria and
a description of the source population. Because the relevance of such variables
as age and sex to the object of research is not always clear, authors should
explain their use when they are included in a study report; for example, authors
should explain why only subjects of certain ages were included or why women
were excluded. The guiding principle should be clarity about how and why a
study was done in a particular way. When authors use variables such as race
or ethnicity, they should define how they measured the variables and justify
Technical information: Identify the methods, apparatus (give the manufacturer's
name and address in parentheses), and procedures in sufficient detail to allow
other workers to reproduce the results. Give references to established methods,
including statistical methods (see below); provide references and brief descriptions
for methods that have been published but are not well known; describe new or
substantially modified methods, give reasons for using them, and evaluate their
limitations. Identify precisely all drugs and chemicals used, including generic
name(s), dose(s), and route(s) of administration.
Authors submitting review manuscripts should include a section describing the
methods used for locating, selecting, extracting, and synthesizing data. These
methods should also be summarized in the abstract.
Reports of randomized clinical trials should present information on all major
study elements, including the protocol, assignment of interventions (methods
of randomization, concealment of allocation to treatment groups), and the method
of masking (blinding), based on the CONSORT Statement (Moher D, Schulz KF,
Altman DG: The CONSORT Statement: Revised Recommendations for Improving the
Quality of Reports of Parallel-Group Randomized Trials. Ann Intern Med. 2001;134:657-662,
also available at http://www.consort-statement.org).
Authors submitting review article should include a section describing the
methods used for locating, selecting, extracting, and synthesizing data. These
methods should also be summarized in the abstract.
When reporting experiments on human subjects, indicate whether the procedures
followed were in accordance with the ethical standards of the responsible committee
on human experimentation (institutional or regional) and with the Helsinki
Declaration of 1975, as revised in 2000 (available at http://www.wma.net/e/policy/17-c_e.html).
Do not use patients' names, initials, or hospital numbers, especially in illustrative
material. When reporting experiments on animals, indicate whether the institution's
or a national research council's guide for, or any national law on the care
and use of laboratory animals was followed.
When possible, quantify findings and present them with appropriate indicators
of measurement error or uncertainty (such as confidence intervals). Report
losses to observation (such as dropouts from a clinical trial). Put a general
description of methods in the Methods section. When data are summarized in
the Results section, specify the statistical methods used to analyze them.
Avoid non-technical uses of technical terms in statistics, such as 'random'
(which implies a randomizing device), 'normal', 'significant', 'correlations',
and 'sample'. Define statistical terms, abbreviations, and most symbols.
Use upper italics (P 0.048). For all P values include the exact value and
not less than 0.05 or 0.001.
Present your results in logical sequence in the text, tables, and illustrations,
giving the main or most important findings first. Do not repeat in the text
all the data in the tables or illustrations; emphasize or summarize only
important observations. Extra or supplementary materials and technical detail
can be placed in an appendix where it will be accessible but will not interrupt
the flow of the text; alternatively, it can be published only in the electronic
version of the journal.
When data are summarized in the Results section, give numeric results not
only as derivatives (for example, percentages) but also as the absolute numbers
from which the derivatives were calculated, and specify the statistical methods
used to analyze them. Restrict tables and figures to those needed to explain
the argument of the paper and to assess its support. Use graphs as an alternative
to tables with many entries; do not duplicate data in graphs and tables. Avoid
non-technical uses of technical terms in statistics, such as "random" (which
implies a randomizing device), "normal," "significant," "correlations," and "sample."
Where scientifically appropriate, analyses of the data by variables such as
age and sex should be included.
Include Summary of key findings (primary outcome measures, secondary outcome
measures, results as they relate to a prior hypothesis); Strengths and limitations
of the study (study question, study design, data collection, analysis and
interpretation); Interpretation and implications in the context of the totality
of evidence (is there a systematic review to refer to, if not, could one
be reasonably done here and now?, what this study adds to the available evidence,
effects on patient care and health policy, possible mechanisms); Controversies
raised by this study; and Future research directions (for this particular
research collaboration, underlying mechanisms, clinical research). Do not
repeat in detail data or other material given in the Introduction or the
In particular, contributors should avoid making statements on economic benefits
and costs unless their manuscript includes economic data and analyses. Avoid
claiming priority and alluding to work that has not been completed. State new
hypotheses when warranted, but clearly label them as such.
As an appendix to the text, one or more statements should specify 1) contributions
that need acknowledging but do not justify authorship, such as general support
by a departmental chair; 2) acknowledgments of technical help; and 3) acknowledgments
of financial and material support, which should specify the nature of the
support. This should be included in the title page of the manuscript.
References should be numbered consecutively in the order in which they are
first mentioned in the text (not in alphabetic order). Identify references
in text, tables, and legends by Arabic numerals in square bracket (e.g. ).
References cited only in tables or figure legends should be numbered in accordance
with the sequence established by the first identification in the text of
the particular table or figure. Use the style of the examples below, which
are based on the formats used by the NLM in Index Medicus. The titles of
journals should be abbreviated according to the style used in Index Medicus.
Use complete name of the journal for non-indexed journals. Avoid using abstracts
as references. Information from manuscripts submitted but not accepted should
be cited in the text as "unpublished observations" with written
permission from the source. Avoid citing a "personal communication" unless
it provides essential information not available from a public source, in
which case the name of the person and date of communication should be cited
in parentheses in the text. For scientific articles, contributors should
obtain written permission and confirmation of accuracy from the source of
a personal communication.
The commonly cited types of references are shown here, for other types of
references such as electronic media, newspaper items, etc. please refer to
(http://www.icmje.org or http://www.nlm.nih.gov/bsd/uniform_requirements.html).
Articles in Journals
1. Standard journal article: Kulkarni SB, Chitre RG, Satoskar RS. Serum proteins
in tuberculosis. J Postgrad Med 1960;6:113-20.
List the first six contributors followed by et al.
2. Volume with supplement: Shen HM, Zhang QF. Risk assessment of nickel carcinogenicity
and occupational lung cancer. Environ Health Perspect 1994; 102 Suppl 1:275-82.
3. Issue with supplement: Payne DK, Sullivan MD, Massie MJ. Women's psychological
reactions to breast cancer. Semin Oncol 1996; 23(1, Suppl 2):89-97.
Books and Other Monographs
4. Personal author(s): Ringsven MK, Bond D. Gerontology and leadership skills
for nurses. 2nd ed. Albany (NY): Delmar Publishers; 1996.
5. Editor(s), compiler(s) as author: Norman IJ, Redfern SJ, editors. Mental
health care for elderly people. New York: Churchill Livingstone; 1996.
6. Chapter in a book: Phillips SJ, Whisnant JP. Hypertension and stroke. In:
Laragh JH, Brenner BM, editors. Hypertension: pathophysiology, diagnosis, and
management. 2nd ed. New York: Raven Press; 1995. pp. 465-78.
- Tables should be self-explanatory and should not duplicate textual material.
- Tables with more than 10 columns and 25 rows are not acceptable.
- Type or print out each table with double spacing on a separate sheet of
paper. If the table must be continued, repeat the title on a second sheet
- Number tables, in Arabic numerals, consecutively in the order of their
first citation in the text and supply a brief title for each.
- Place explanatory matter in footnotes, not in the heading.
- Explain in footnotes all non-standard abbreviations that are used in each
- Obtain permission for all fully borrowed, adapted, and modified tables
and provide a credit line in the footnote.
- For footnotes use the following symbols, in this sequence: *, †, ‡, §,
||, , **, ††, ‡‡
- Submit three sets of figures.
- Send sharp, glossy, un-mounted, color photographic prints, with height
of 4 inches and width of 6 inches.
- Figures should be numbered consecutively according to the order in which
they have been first cited in the text.
- Each figure should have a label pasted (avoid use of liquid gum for pasting)
on its back indicating the number of the figure, the running title, top
of the figure and the legends of the figure. Do not write the contributor/s'
Do not write on the back of figures, scratch, or mark them by using paper
- Labels, numbers, and symbols should be clear and of uniform size. The
lettering for figures should be large enough to be legible after reduction
to fit the
width of a printed column.
- Symbols, arrows, or letters used in photomicrographs should contrast with
the background and should marked neatly with transfer type or by tissue overlay
and not by pen.
- Titles and detailed explanations belong in the legends for illustrations
not on the illustrations themselves.
- When graphs, scatter-grams or histograms are submitted the numerical data
on which they are based should also be supplied.
- The photographs and figures should be trimmed to remove all the unwanted
- If photographs of people are used, either the subjects must not be identifiable
or their pictures must be accompanied by written permission to use the
- If a figure has been published, acknowledge the original source and submit
written permission from the copyright holder to reproduce the material.
A credit line should appear in the legend for figures for such figures.
- Print outs of digital photographs are not acceptable. For digital images
send TIFF files of minimum 1200 x 1600 pixel size.
- The Journal reserves the right to crop, rotate, reduce, or enlarge the
photographs to an acceptable size.
- Legends for Illustrations
- Type or print out legends (maximum 40 words, excluding the credit line)
for illustrations using double spacing, with Arabic numerals corresponding
- When symbols, arrows, numbers, or letters are used to identify parts of
the illustrations, identify and explain each one in the legend.
- Explain the internal scale and identify the method of staining in photomicrographs.
Protection of Patients' Rights to Privacy
Identifying information should not be published in written descriptions, photographs,
sonograms, CT scans, etc., and pedigrees unless the information is essential
for scientific purposes and the patient (or parent or guardian) gives written
informed consent for publication. Informed consent for this purpose requires
that the patient be shown the manuscript to be published. When informed consent
has been obtained, it should be indicated in the article and copy of the
consent should be attached with the covering letter.
- The manuscript must be accompanied by a 3.5 inch (1.44 MB) floppy or CD containing
- Use a new diskette or fully format the diskette before use. There should
be no other document, file, and material on the diskette other than the final
manuscript. Text, references, tables and legends, all should be in one
- Label each diskette with first contributor's name, short title of the
article, software (e.g. MS Word), version (e.g. 7.0) and file name. Name
the file on
the diskette with the corresponding contributor's last name (up to eight
characters) and a three-letter extension to signify the format (e.g. sharma.doc).
revised manuscript name the file with the manuscript number (e.g. jcrt58).
Use any word-processing program (e.g. Microsoft Word, Word Perfect) or
provide text files.
- Do not use 'oh' (O) for 'zero' (0), 'el' (l) for one (1). Do not use space
bar for indentation. Do not type headings or any other text in ALL CAPITALS.
Do not break words at the end of lines. Do not use an extra hard return/enter
between paragraphs. Do not insert a tab, indent, or extra spaces before
beginning of a paragraph. Do not use software's facility of automatic referencing,
headers, footers, etc.
- Use a hyphen only to hyphenate compound words. Use only one letter space
at the end of sentence. Use hard return/enter only at the end of paragraphs
display lines (e.g. titles, headings and subheadings). Incorporate notes
or footnotes in the text, within parentheses, rather than their usual place
the foot of the page.
- Use single space between lines for the manuscript on the floppy. Provide
the tables and charts at the appropriate place in the text and not at the
- Care should be taken to prevent damage to floppy while sending it through
Sending a revised manuscript
While submitting a revised manuscript, contributors are requested to include,
along with single copy of the final revised manuscript, a photocopy of the
revised manuscript with the changes underlined in red and copy of the comments
with the point to point clarification to each comment. The manuscript number
should be written on each of these documents. If the manuscript is submitted
online, the contributors' form and copyright transfer form has to be submitted
in original with the signatures of all the contributors within two weeks of
submission. Hard copies of images should be sent to the office of the journal.
There is no need to send hard copies of the manuscript for articles submitted
A photocopy of the first page of all the cited references (articles and books)
can be asked by the journal to verify the references.
Journal provides no free printed reprints. It is mandatory to purchase minimum
reprints, payment for which should be done at the time of submitting the proofs.
The whole of the literary matter in the Journal of Cancer Research and Therapeutics
is copyright and cannot be reproduced without the written permission of the
(to be tick marked as applicable and one copy attached with the manuscript)
- Signed by all contributors
- Previous publication / presentations mentioned
- Source of funding mentioned
- Conflicts of interest disclosed
- Middle name initials provided
- Author for correspondence, with e-mail address provided
- Number of contributors restricted as per the instructions
- Identity not revealed in paper except title page (e.g. name of the institute
in Methods, citing previous study as 'our study', names on figure labels,
name of institute in photographs, etc.)
Presentation and format
- Double spacing
- Margins 2.5 cm from all four sides
- Title page contains all the desired information
- Running title provided (not more than 50 characters)
- Abstract page contains the full title of the manuscript
- Abstract provided (about 150 words for case reports and 250 words for original
Structured abstract provided for an original article
- Key words provided (three or more)
- Introduction of 75-100 words
- Headings in title case (not ALL CAPITALS)
- References cited in square brackets
- References according to the journal's instructions, punctuation marks
Language and grammar
- Uniformly American English
- Abbreviations spelt out in full for the first time
- Numerals from 1 to 10 spelt out
Numerals at the beginning of the sentence spelt out
Tables and figures
- No repetition of data in tables and graphs and in text
- Actual numbers from which graphs drawn, provided
- Figures necessary and of good quality (colour)
- Table and figure numbers in Arabic letters (not Roman)
- Labels pasted on back of the photographs (no names written)
- Figure legends provided (not more than 40 words)
- Patients' privacy maintained (if not permission taken)
- Credit note for borrowed figures/tables provided
- Manuscript provided on a floppy (with single spacing)
(to be modified as applicable and one singed copy attached with the manuscript)
Manuscript Title: ____________________________________________________________________________________
I/we certify that I/we have participated sufficiently in the intellectual
content, conception and design of this work or the analysis and interpretation
of the data (when applicable), as well as the writing of the manuscript, to
take public responsibility for it and have agreed to have my/our name listed
as a contributor.
I/we believe the manuscript represents valid work. Neither this manuscript
nor one with substantially similar content under my/our authorship has been
published or is being considered for publication elsewhere, except as described
in the covering letter. I/we certify that all the data collected during the
study is presented in this manuscript and no data from the study has been or
will be published separately. I/we attest that, if requested by the editors,
I/we will provide the data/information or will cooperate fully in obtaining
and providing the data/information on which the manuscript is based, for examination
by the editors or their assignees. Financial interests, direct or indirect,
that exist or may be perceived to exist for individual contributors in connection
with the content of this paper have been disclosed in the cover letter. Sources
of outside support of the project are named in the cover letter.
I/We hereby transfer(s), assign(s), or otherwise convey(s) all copyright ownership,
including any and all rights incidental thereto, exclusively to the Journal
of Cancer Research and Therapeutics, in the event that such work is published
by the Journal of Cancer Research and Therapeutics. The Journal of Cancer Research
and Therapeutics shall own the work, including 1) copyright; 2) the right to
grant permission to republish the article in whole or in part, with or without
fee; 3) the right to produce preprints or reprints and translate into languages
other than English for sale or free distribution; and 4) the right to republish
the work in a collection of articles in any other mechanical or electronic
We give the rights to the corresponding author to make necessary changes as
per the request of the journal, do the rest of the correspondence on our behalf
and he/she will act as the guarantor for the manuscript on our behalf.
All persons who have made substantial contributions to the work reported in
the manuscript, but who are not contributors, are named in the Acknowledgment
and have given me/us their written permission to be named. If I/we do not include
an Acknowledgment that means I/we have not received substantial contributions
from non-contributors and no contributor has been omitted.
Name Signature Date signed
1 ------------ --------- ---------------
2 ------------ --------- ---------- -----
3 ------------ --------- ---------- -----
4 ------------ --------- ---------- ----- (up to 4 contributors for case report/images/review)
5 ------------ --------- ---------- -----
6 ------------ --------- ---------- ----- (up to 6 contributors for original
Copyright 2005 - Journal of Cancer Research and Therapeutics