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REVIEWS A.S. Khokhlov: Microbial Autoregulators. Harwood Academic Publishers, Chur Reading-Paris-Philadelphia-Tokyo-Melbourne. 16 Chapters and Addenda to the English Edition. 450 pp 1991 (in English). V.D.KUZNETSOV Institute of Microbiology, USSR Academy of Sciences, 117811 Moscow, USSR
Code Number: AC92004
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A review of the Russian edition (1988) of Khokhlov's book
by Professor G. Szabo was published in Actinomycetes
(Vol. 1: 25-26, 1990). This is a short review of the
English translation and enlarged edition, published in
1991.It contains the full text (with some small corrections) of the original book with an Addendum. Professor G. Szabo concluded that this book was a special and pioneering work, "not just a compilation of chapters from sources by other authors ". The new edition has the advantage of an English translation and a up-date of the subject. The Addendum includes data from more than 130 papers not included in the first edition. These are presented briefly, but are selected to increase our understanding of the new autoregulators. Thus 19 new structural formulae of autoregulators are presented. These include a new sex pheromone cCF 10 of Streptococcus faecalis and proteins involved in bioluminescence. Other papers quoted show the wide distribution of the cosynthetic factor in nature and its role in the process of lincomycin biosynthesis. Many publications concerning the Afactor and its analogues from different actinomycetes are also included. For some time in the past autoregulators from yeasts have attracted great attention. Publications devoted to final structure elucidation and synthesis of a factor produced by Saccharomyces cerevisiae are considered. Finally the structure and synthesis of a potent autoregulator DIF-l from Dictyostelium discoideum are discussed. The English translation is very accurate, with few misprints; the chemical formulae and schemes are very clear. The reviewer can make only a few remarks. These are some mistakes in the names of the autoregulators in the Index: Kerosin instead of Keerosin; Nonanin acid instead of Nonaic acid; Pomamycin instead of Pamamycin. In the short annotation of the book (see: last page of the book-cover) it is stated that the book contains only 27 chemical formulae. The reviewer noted more than 250 numbered formulae. As a general conclusion I recommend this very interesting and carefully written book to microbiologists, mycologists, biochemists, molecular biologists and experts in the chemistry of natural compounds as well as to the advanced students of these specialities.
Copyright 1995 CETA
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