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Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
ISSN: 0019-509X EISSN: 1998-4774
Vol. 39, Num. 3, 2002, pp. 116-118
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Indian Journal of Cancer, Vol. 39, No. 3, (July - September 2002), pp. 116-118
Metastatic Invasive Mole in the Urinary Bladder
Bhawna Malhotra, M.D., Senior Research Associate, Renu Misra, M.D.,
Associate Professor
Department of Obstetrics & Gynecology, All India Institute of Medical
Sciences, New Delhi, India.
Code Number: cn02006
ABSTRACT
We report an unusual case of invasive mole metastasized to the urinary bladder. The patient
presented with hematuria one month after evacuation of a molar pregnancy. The serum chorionic
gonadotropin levels regressed spontaneously following transurethral cystoscopic resection of the tumour. Metastasis
of an invasive mole to the urinary bladder has not been previously reported.
INTRODUCTION
Invasive mole follows approximately 10 to 15 per cent of complete hydatidiform
moles.1 They are characterized by the persistence
of edematous chorionic villi with trophoblastic proliferation invading into the
myometrium. Invasive moles rarely metastasize and the
most common sites of metastatic lesions are lung, vagina, parametrium and pelvis. Brain,
liver, spleen, kidneys and retroperitoneum are the
other reported rare sites of metastatic
mole.2-4 To the best of our knowledge, metastasis of an
invasive mole to the urinary bladder has not been
reported in the literature, though choriocarcinoma of
the urinary bladder has been described in a case
report.5 The presence of villi in the
metastatic trobhoblastic tissue differentiates an
invasive mole from choriocarcinoma. We present a
case of metastatic mole in the urinary bladder diagnosed one month after the evacuation
of hydatidiform mole.
CASE REPORT
A 31-year-old primipara presented in the outpatient department of Gynaecology
at All India Institute of Medical Sciences, New
Delhi, with the complaints of hematuria for three
days and irregular vaginal bleeding for ten days.
One month back, she had undergone uterine
evacuation for a molar pregnancy at a period of three and a half months gestation
at a peripheral hospital. She had not attended any follow-up
nor serum chorionic gonadotropin levels (hCG) had been assayed before or after
the evacuation. Her previous menstrual history was unremarkable. Her past
obstetric history included a
cesarean section at term two years back.
The general and systemic examination revealed no abnormality. On local
examination, the external genitalia and urethral meatus
were healthy. The speculum examination revealed a healthy vagina and cervix with minimal
bleeding from the cervical os. On bimanual pelvic examination, the uterus was anteverted
and multiparous size. There was no tenderness or adnexal mass palpable in any of the fornices.
The urine examination confirmed hematuria with no evidence of infection on microscopy or
culture. Routine serum biochemistry and chest X-ray
were normal. Her serum beta-hCG was 406 MIU\ml. The pelvic ultrasound showed a
space-occupying lesion in the urinary bladder with
mucosal thickening and irregularity in the
posterior bladder wall. The uterus and bilateral
ovaries were unremarkable.
The cystoscopy confirmed a solitary lobulated growth, 2.5 x 1.0 cm in size,
arising near the right ureteric orifice and extending
to the trigone; bleeding on touch. The growth was resected using the resectoscope
at the same sitting, followed by a uterine curettage. The histopathology of
both the specimens was
similar and consistent with hydatidiform mole, with
areas of hemorrhage and necrosis in the bladder specimen.
The metastatic work-up revealed no evidence of metastasis at any other site. In
view of low levels of serum beta-hCG, she was kept under surveillance with serial quantitative
beta-hCG determinations to consider chemotherapy
if beta-hCG levels plateau or rise.
Post-operatively, beta-hCG fell rapidly to 37mIU\n1 at one
week and <5mlU\ml at two weeks following the resection of the tumour. The subsequent
beta-hCG levels were negative till 18months of follow-up.
DISCUSSION
Complete hydatidiform moles are recognized to have a potential for
developing uterine invasion or distant metastases
(which represent the normal capacity of the
trophoblast for implantation). Approximately 20 per cent
of patients with primary hydatidiform mole develop malignant sequelae, the majority of which
are invasive moles.6 Invasive mole may
perforate through the myometrium resulting in
uterine perforation and intraperitoneal
bleedmg.7 Direct vascular invasion and metastasis rarely occur
in invasive moles; the most common site reported is the
lung.2,8
The metastatic mole is frequently diagnosed incorrectly as
choriocarcinomar.2 The diagnosis of invasive mole rests on
the demonstration of complete hydatidiform mole invading the myometrium or the presence of
villi in the metastatic lesion (as was present in
our case). Myometrial invasion is difficult to document on pelvic ultrasound and also in
uterine curettings unless there is sufficient
myometrium to demonstrate invasion. The metastatic
lesion may not be available for the pathological diagnosis in all the cases.
The use of prophylactic chemotherapy following molar evacuation remains
controversial.
Although it has been shown to reduce the incidence of persistent or metastatic
gestational trophoblastic neoplasia, it is not routinely recommended.
The low morbidity and mortality achieved by monitoring patients with serial beta-hCG
levels and instituting only indicated chemotherapy outweighs, the potential
risk and small benefit
of routine prophylactic
chemotherapy.1,6 The role of chemotherapy in the management of invasive
mole is debatable, with the evidence of
spontaneous regression of metastatic mole in the
literature.2,8 Ring reported two patients with
histologically proven metastases from hydatidiform mole to
the lungs, which regressed spontaneously following hysterectomy without additional
chemotherapy.8 In a review of twenty cases of invasive
mole, Wilson et al reported that no additional
therapy was administered for metastatic lesion in
three cases all of whom recovered with
disappearance of metastatic lesion.2
In our patient, the metastatic mole in the urinary bladder was detected one month after
the evacuation of molar pregnancy due to the occurrence of hematuria. Since beta-hCG
was low at that time, it is possible that serum
hCG levels were already regressing following molar evacuation when hematuria resulted
from necrosis and degeneration of the metastatic
mole. It remains uncertain whether cystoscopic resection of the metastatic mole provided
any additional benefit in the management of our case.
We did not consider chemotherapy in our case as the beta-hCG was already low and
thereafter declined rapidly to become negative. Low
beta-hCG levels before treatment and negative hCG
as early as one week following treatment has been reported in association with histologically
proven metastatic mole.2 Pronounced degenerative
changes in the trophoblasts along with hyalinization
were found to correlate with low or declining levels
of beta-hCG.
Though experience in the management of metastatic mole is limited, we believe
that surgical removal of the metastatic lesion
should be done whenever possible. It would provide tissue diagnosis as well as
hasten the resolution of the disease. In our opinion,
chemotherapy
should not be withheld in the presence of metastasis in association with high
hCG titer
since
invasive mole can perforate to result in a potentially fatal hemorrhage.
REFERENCES
- Hammond CB. Gestational trophoblastic neoplasms. In: Scott JR, DiSaia PJ,
Spellacy WN, eds. Danforth's Obstetrics and Gynecology, 8th edn. Philadelphia:
Lippincott Williams & Wilkins; 1999. pp. 927-37.
- Wilson RB, Hunter IS, Dockerty MB. Chorioadenoma destruens. Am J Obstet
Gynecol 1961;81:546-59.
- Song HZ, Yang XY, Xiang Y. Forty-five
years' experience of the treatment of
choriocarcinoma and invasive mole. Int J Gynecol
Obstet 1998;160:S77-83.
- Makangee A, Nadvi SS, Dellen JRV.
Invasive mole presenting as a spinal extradural
tumour: Case report. Neurosurgery 1996;38:191-3.
- Yishai D, Atad J, Bornstein J, et al. Choriocarcinoma of the bladder: Report
of a case of primary tumour or late metastasis of a molar pregnancy. J
Reprod Med 1995;40:482-4.
- ACOG Technical Bulletin. Management of gestational trophoblastic disease.
Int J
Gynecol Obstet 1993;142:308-15.
- Mackenzie F, Mathers A, Kennedy J,
Invasive hydatidiform mole presenting as an acute primary haemoperitoneum.
Br J Obstet
Gynecol 1993;100:953-4.
- Ring AM. The concept of benign
metastasizing hydatidiform moles. Am J Clin Path 1972;58:111-7.
Copyright 2002 - Indian Journal of Cancer.
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