|
Indian Journal of Cancer, Vol. 46, No. 2, April-June, 2009, pp. 174-175 Letter To Editor Primary brain sarcoma or metastatic carcinoma? Walid MS, Osborne TJ, Robinson JS Jr Medical Center of Central Georgia, 840 Pine Street, Suite 880, Macon, GA 31201, USA Code Number: cn09035 Sir, Primary brain sarcomas are very rare tumors with less than 50 cases reported since 1929. [1],[2] We are describing the case of a patient with sarcoidosis and treated breast carcinoma who presented 18 years later with brain tumor, whose pathological features were more consistent with primary sarcoma of the brain. A 56-year-old African-American woman presented with recent-onset confusion. The patient′s history was significant for right mastectomy with transverse rectus abdominus myocutaneous flap reconstruction in 1989, total abdominal hysterectomy, and sarcoidosis. Physical examination and review of systems were remarkable for cough, delayed verbal response, and right-sided hemiparesis. Computed tomography (CT) images of the thorax, abdomen, and pelvis revealed mediastinal and hilar adenopathy. Brain magnetic resonance imaging (MRI) showed an intra-axial mass in the left frontal lobe with significant surrounding vasogenic edema and mild mass effect upon the surrounding structures [Figure - 1]. The mass demonstrated intense contrast enhancement with findings suggestive of central necrosis. Bilateral digital diagnostic mammogram with computer-aided detection (CAD) was negative. The patient was started on IV steroids and was taken to the operating room for craniotomy and excision of the mass on day one of hospitalization. Operative intervention revealed a hard, well-encapsulated lesion that was easily removed from the brain. The frozen section revealed sarcoma-type features. Immunohistochemistry showed that the tumor was negative for desmin, smooth muscle actin, S100, epithelial membrane antigen (EMA), glial fibrillary acidic protein (GFAP), and MOC-31. There was some positive staining with pankeratin [Figure - 2]; however, this was interpreted as cross-reactivity with nonkeratin intermediate filaments. The vimentin and P16 staining were strongly positive. The GFAP and S100 stains highlighted the entrapped reactive astrocytes, with no evidence of a neoplastic glial component. P53 demonstrated 4+ nuclear staining in greater than 66% of the neoplastic cells. The Ki-67 labeling index was> 50% and mitoses were 11 per 10 high power fields. Bcl-2 and repeat EMA stains were negative and the reticulin pattern was consistent with entrapped glial cells. Additional molecular diagnostic testing was performed, which showed no evidence of Phosphatase and tensin homolog (PTEN) deletions or epidermal growth factor receptor (EGFR) amplifications. The final diagnosis was spindle cell sarcoma, Fιdιration Nationale des Centres de Lutte Contre le Cancer (FNCLCC) grade 3. The old pathological report of the patient′s breast cancer was retrieved; it indicated comedo type intraductal carcinoma, which meant the brain tumor was a primary sarcoma of the brain. The slides were sent to another hospital for consultation and the report came favoring metastatic carcinoma over primary or metastatic sarcoma in view of the strong and diffuse expression of cytokeratin. The etiology of primary brain sarcomas is not well-established. Genetic, viral, and environmental factors have been implicated. Brain sarcoma has been reported years after radio- and chemotherapy. [3] Meningiomas have also been reported years after breast cancer treated with chemotherapy. [4] Our patient was successfully treated for breast cancer 18 years ago and old chemotherapy could have played a role in the genesis of her brain sarcoma. Besides, cases of Kaposi sarcoma associated with sarcoidosis have been described in literature. [5] In our case, primary sarcoma of the brain could be linked to previous chemotherapy and sarcoidosis. Understanding how these factors relate to each other requires further investigation. Finally, if this was a dedifferentiated metastasis from breast carcinoma, it would still be a rare case because of the long period that had passed before it revealed itself with a different tissue type. References
Copyright 2009 - Indian Journal of Cancer The following images related to this document are available:Photo images[cn09035f1.jpg] [cn09035f2.jpg] |
|