Indian Journal of Cancer Medknow Publications on behalf of Indian Cancer Society ISSN: 0019-509X EISSN: 1998-4774 Vol. 48, Num. 3, 2011, pp. 378-378

Indian Journal of Cancer, Vol. 48, No. 3, July-September, 2011, pp. 378

Letter to Editor

Ki-67 as proliferative marker of thyroid

V Wiwanitkit

Wiwanitkit House, Bangkhae, Bangkok - 10160, Thailand
Correspondence Address: V Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok - 10160, Thailand, wviroj@yahoo.com

Code Number: cn11104

PMID: 21921351

DOI: 10.4103/0019-509X.84927

Sir,

I read the recent report by Pujani et al. with a great interest. They concluded that "Ki-67 was found to be useful in differentiating between follicular adenoma and follicular carcinoma, but since the sample size of our study was small, larger studies are needed to confirm this observation as well as to assign a cutoff value for differentiating benign from malignant tumors." ^[1] As Pujani et al. noted, there are some limitations due to methodology of this report. Not only the few subjects but also no age and sex matched case control design are big problems that limit the clinical usefulness of this work. Indeed, there are also other left questions. The problems on the immunostaining of Ki-67 should also be discussed. False positive and false negative due to Ki- 67 tests are already reported in the study in colorectal cancer. ^[2]

References

1.	Pujani M, Arora B, Pujani M, Singh SK, Tejwani N. Role of Ki-67 as a proliferative marker in lesions of thyroid. Indian J Cancer 2010;47:304-7.  Back to cited text no. 1  [PUBMED]
2.	Kuniyasu H, Oue N, Shigeishi H, Ito R, Kato Y, Yokozaki H, et al. Prospective study of Ki-67 labeling index in the mucosa adjacent to cancer as a marker for colorectal cancer metastasis. J Exp Clin Cancer Res 2001;20:543-8.  Back to cited text no. 2  [PUBMED]

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